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In-situ estimation of li-ion battery state-of-health using on-board electrical measurement for electromobility applications
(2025) García Bustos, Jorge Eduardo; Brito Schiele, Benjamín; Baldo, Leonardo; Masserano, Bruno; Jaramillo Montoya, Francisco; Troncoso Kurtovic, Diego; Orchard, Marcos E; Pérez Mora, Aramis; Silva, Jorge F.
The well-balanced combination of high energy density and competitive cycle performance has established lithium-ion batteries as the technology of choice for Electric Vehicles (EV) energy storage. Nevertheless, battery degradation continues to pose challenges to EV range, safety, and long-term reliability, making accurate estimation of their State of Health (SoH) crucial for efficient battery management, safety, and improved longevity. This paper addresses a compelling research question: the development of a real-time, non-invasive, and efficient methodology for estimating lithium-ion battery SoH without battery removal, relying solely on voltage and current data. Our approach integrates the fitting abilities of MaximumLikelihood Estimation (MLE) with the dynamic uncertainty propagation of Bayesian Filtering to provide accurate and robust online SoH estimation. By reconstructing the open-circuit voltage curve from real-time data, the MLE estimates battery capacity during discharge cycles, while Bayesian Filtering refines these estimates, accounting for uncertainties and variations. The methodology is validated using an available dataset from Stanford University, demonstrating its effectiveness in tracking battery degradation under driving profiles. The results indicate that the approach can reliably estimate the battery SoH with a mean absolute error around 1%, highlighting its potential for scalable applications in different types of lithium-ion cells and battery configurations in EVs.
Laboratorios itinerantes de innovación pública. Estrategia de gestión del conocimiento para lo público-territorial
(2025-10-15) Tapia Góngora, Edwin Manuel
La pérdida de confianza en los gobiernos y la democracia de la región (Latinobarómetro, 2023) ha hecho visible los límites de la gestión de lo público basada solo en consensos tecnocráticos. Esto plantea la necesidad de buscar nuevos caminos que a la vez que permitan superar los problemas públicos recurrentes, contribuyan a mejorar la legitimidad y confianza en la capacidad de las administraciones públicas y los gobiernos. En noviembre de 2022, en la sede Valledupar de la Escuela Superior de Administración Pública (ESAP) de Colombia, el denominado Centro Territorial en Administración Pública (CETAP), se realizó un foro sobre la situación de la pobreza en la región. Este espacio no solo arrojó luces sobre los programas sociales dispuestos antes, durante y luego de la pandemia, sino que abrió interrogantes sobre la conexión entre la efectividad de la innovación pública y la legitimidad de estos procesos. El siguiente artículo trata sobre la experiencia de implementación de la primera fase del Laboratorio Itinerante en Innovación en el CETAP Valledupar, acaecido entre noviembre de 2022 y septiembre de 2024. El documento se divide en cinco partes: Introducción, métodos y materiales, resultados, discusión y conclusión. En el método, se consigna el alcance espacial, temporal y variables de análisis; en los resultados, se presentan los productos generados; en la discusión, se presentan una reflexión sobre la dimensión política de la innovación pública, y; en las conclusiones, se enuncian unos retos en gestión del conocimiento para la innovación pública en contextos signados por el
patrimonialismo y despolitización de las esferas de lo público estatal.
Modules of correlated genes in a gene expression regulatory network of CDDP-resistant cancer cells
(2018-09-13) Jiménez Vargas, Dennis; Acón, Man Sai; Sahin, Özgür; Eyüpoğlu, Erol; Riazalhosseini, Yasser; Molina Mora, José Arturo; Guevara Coto, José Andrés; Mora Rodríguez, Rodrigo Antonio
Chemotherapeutic drugs have been used as important strategies in cancer treatment. However, chemotherapy-resistant tumors arise especially in relapsing and progressive disease. Understanding of mechanisms underlaying Cisplatin-CDDP chemotherapy resistance may help find new therapeutic targets to revert this phenotype. The aim of this work, through an integrative Systems Biology approach, is to optimize an in silico model of TFs-miRNAs gene expression regulatory network of CDDP-chemoresistant cancer cell lines. By identifying modules of co-expressed genes in this regulatory network we expect further understanding of CDDP-chemoresistant phenotype. A set of deregulated genes was determined for two CDDP-chemoresistant cancer cell lines by considering gene copy number and transcriptomics. These genes were used as input targets for the construction and fitting of a large scale ordinary differential equations (ODE) model using our biocomputational platform previously reported. Model optimization was performed using COPASI and modules of correlated genes were determined using WGCNA. A model of 108 deregulated target genes, 44 transcription factors and 21 miRNAs was successfully constructed and optimized. Eleven modules of correlated genes were determined along with their gene product annotation. This report contributes to the understanding of the complex regulatory networks of CDDP-resistance and the future design of therapeutic strategies to overcome drug resistance.
In silico Identification of miRNA as possible therapeutic targets for Micro Invasive Bladder Cancer (MIBC) treatment
(2023-02-02) Leitón Arrieta, Sylvia; Montero Vargas, Maripaz; Mora Rodríguez, Rodrigo Antonio
Urothelial bladder cancer is the fourth most common malignancy in incidence in men, ranking eighth in mortality; while in women it is not in the top 10 in incidence or mortality. Advanced age is the main risk factor, with a median age at diagnosis between 70 and 84 years, with women 3 to 4 times less at risk than men. This is traditionally attributed to exposure and lifestyle, the use of carcinogens such as tobacco smoke, and exposure to carcinogenic aromatic amines is the second most important risk factor, representing (dyes, rubbers, textiles, paints and leathers) the second highest risk factor. Micro-invasive bladder cancer (MIBC) requires patients to undergo long-term invasive surveillance with diagnostic and therapeutic cystoscopy. The treatment of MIBC is undergoing rapid changes, as immunotherapy with checkpoint inhibitors, targeted therapies and antibody conjugates have become possible therapeutic options, and the identification of potential therapeutic targets with miRNAs is of increasing research interest.
Approaches for Transformative Health Systems in Latin America
(2025) IFIC LatAm; Sáenz Madrigal, María del Rocío
The presentation explores the adaptation of the SCIROCCO model to Latin American health systems, emphasizing the need for contextualized approaches to integrated care. It highlights the complexity and diversity of regional health structures and proposes a framework that incorporates transformational leadership, participatory governance, and systemic thinking. The model is reinterpreted to reflect person-, family-, and community-centered care, with a strong focus on equity, continuous training, and adaptive strategies. The goal is to guide the scaling of integrated care through locally grounded diagnostics, interdisciplinary collaboration, and culturally relevant policy development.