Listar por autor "Jorge, L. F."
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The oxidative metabolism of sparteine in the Cuna Amerindians of Panama: Absence of evidence for defient metabolizers
Arias, Tomas D.; Jorge, L. F.; Lee, D; Barrantes Mesén, Ramiro; Inaba, T. (1988-04-20)Sparteine sulfate (50 mg) was administered to 170 Cuna Amerindians, 142 of whom were unrelated, and the drug and its dehydrometabolites were determined in the 0- to 12-hour urine samples. The log10 of the metabolic ratio ... -
Uses and misuses of definitions of genetic polymorphism: A perspective from population pharmacogenetics
Arias, Tomas D.; Jorge, L. F.; Barrantes Mesén, Ramiro (1991)Definitions of genetic polymorphism currently employed in the pharmacological literature have been incorrectly used (Kalow, 1984) and uncritically imported from population genetics [e.g., Weinshilboum (1984), Evans (1977)], ...