• A new Pan African polyspecific antivenom developed in response to the antivenom crisis in Africa 

      Laing, Gavin D.; Renjifo, J.M.; Ruiz, F.; Harrison, Robert A.; Nasidi, Abdulsalami; Gutiérrez, José María; Rowley, Paul D.; Warrell, David A.; Theakston, R. David G. (2003-07)
      Currently there is a crisis in the supply of antivenom for treatment of snake bite in sub-Saharan Africa. Commercial pressures have resulted in the reduction or even cessation of production of antivenom by European ...
    • Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: an alternative to the antivenom crisis in Africa 

      Gutiérrez, José María; Rojas Umaña, Ermila; Quesada, L.; León Montero, Guillermo; Núñez, Javier; Laing, Gavin D.; Sasa Marín, Mahmood; Renjifo, J.M.; Nasidi, Abdulsalami; Warrell, David A.; Theakston, R. David G.; Rojas Céspedes, Gustavo (2005-06)
      A polyspecific Pan-African antivenom has been produced from the plasma of horses immunized with a mixture of the venoms of Echis ocellatus, Bitis arietans and Naja nigricollis, the three most medically important snakes in ...
    • Polyspecific snake antivenom may help in antivenom crisis 

      Laing, Gavin D.; Harrison, Robert A.; Theakston, R. David G.; Renjifo, J.M.; Nasidi, Abdulsalami; Gutiérrez, José María; Warrell, David A. (2003-02)
      In Africa snakebites cause thousands of deaths annually and much permanent physical disability, but the supply of antivenom, the only specific treatment, is threatened by commercial pressures and privatisation. This has ...
    • Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: In vitro and in vivo gene expression analysis of the effects of the toxin 

      Gallagher, Paul; Bao, Yongde; Serrano, Solange M. T.; Laing, Gavin D.; Theakston, R. David G.; Gutiérrez, José María; Escalante Muñoz, Teresa; Zigrino, Paola; Moura Da Silva, Ana M.; Nischt, Roswitha; Mauch, Cornelia; Moskaluk, Christopher; Fox, Jay W. (2005-09)
      To assess the indirect effects of snake venom metalloproteinases (SVMP) on host tissue local necrosis, we investigated the effect of the SVMP jararhagin on the gene expression profiles of human fibroblasts in vitro and ...