Listar Investigación por procedencia "UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Laboratorio de Ensayos Biológicos (LEBI)"
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Actividad gastroprotectora del extracto etanólico de hojas de Licania platypus (Hemsl.) Fritish
(2017-09-05)La especie Licania platypus, localmente conocida como “sonzapote” se encuentra ampliamente distribuida en países tropicales. Tradicionalmente, en América Central se han utilizado diferentes partes de la planta para diversos ... -
Aposematismo en la rana Phyllobates vittatus (anura: Dendrobatidae): integrando defensas, señales y riesgo de depredación
(2019-10-01)El aposematismo es una estrategia defensiva en la cual animales que poseen una defensa lo advierten a los depredadores a través de una señal conspicua. Por ejemplo, algunos animales tóxicos o con poca palatabilidad le ... -
Biological indicators of animal welfare in rodents in the biological essay laboratory of the University of Costa Rica: Evaluation protocols
(2019)Animal welfare can be affected by many factors that compromise both physical and mental health, that is why the more objective relationships are provided, the greater the likelihood of identifying the state of well-being ... -
Caracterización del extracto acuoso de Lomariopsis japurensis y de la actividad antiespasmódica, mediante un sistema de baño de órganos y su validación en un modelo murino Hsd:ICR
(2023)La Organización Mundial de la Salud ha avalado la implementación de la medicina tradicional en los servicios de atención primaria de salud. Actualmente muchos países trabajan en su implementación (OMS, 2013). Algunas ... -
Comité Institucional para el Cuido y Uso de los Animales (CICUA)
(2018)Se desarrolla los temas de fiscalización y reglamentación para el cuido y uso de animales en laboratorio, además, del procedimiento a seguir para utilizar animales en laboratorio, así como, las responsabilidades de la ... -
Critical Assessment of pH-Dependent Lipophilicity Profiles of Small Molecules: Which One Should We Use and In Which Cases?
(2023-10-03)Lipophilicity is a physicochemical property with wide relevance in drug design, computational biology, food, environmental and medicinal chemistry. Lipophilicity is commonly expressed as the partition coefficient for neutral ... -
Efecto de los analgésicos dipirona, tramadol y meloxicam en el comportamiento de ratas de laboratorio
(2022-11)Awareness about the ethical use of laboratory animals has increased over recent decades alongside the development of strict guidelines and legislation concerning the welfare of animals in scientific research. Although ... -
Efecto del extracto acuoso de hojas de Licania platypus (Hemsl.) Fritsh. Sobre la protección gástrica y la motilidad gastrointestinal
(2018-09-20)Licania platypus se distribuye ampliamente en países tropicales. Tradicionalmente, en América Central se ha utilizado para diversos problemas de salud, especialmente gastrointestinales. Objetivo: Investigar la actividad ... -
Fat Intake and obesity-related parameters predict striatal BDNF gene expression and dopamine metabolite levels in cafeteria diet-fed rats
(2022-04)Modern westernized diet is a major risk factor associated with the current obesity epidemic. To study the effects of dietary choices of Western societies, the cafeteria diet has been validated as a preclinical model of ... -
Helicobacter pylori infection induces gastric precancerous lesions and persistent expression of Angpt2, Vegf-A and Tnf-A in a mouse model
(2023)Helicobacter pylori colonizes the gastric mucosa and induces chronic inflammation. Using a mouse model of H. pylori-induced gastritis, we evaluated the mRNA and protein expression levels of proinflammatory and proangiogenic ... -
Infestación múltiple por ácaros ectoparásitos en conejos de crianza
(2011-06-01)Six breeding rabbits (New Zealand strain) were observed with crusted and pruritic dermal lesions. These lesions were located predominantly in ears, nose, nails and feet. Dermal material collected by scraping showed the ... -
Novel Clade C-I Clostridium difficile strains escape diagnostic tests, differ in pathogenicity potential and carry toxins on extrachromosomal elements
(2018)The population structure of Clostridium difficile currently comprises eight major genomic clades. For the highly divergent C-I clade, only two toxigenic strains have been reported, which lack the tcdA and tcdC genes and ... -
Plant diversity in the diet of Costa Rican primates in contrasting habitats: a meta-analysis
(2023)In human-modified tropical landscapes, the survival of arboreal vertebrates, particularly primates, depends on their plant dietary diversity. Here, we assessed diversity of plants included in the diet of Costa Rican ... -
Proteogenomic analysis of the Clostridium difficile exoproteome reveals a correlation between phylogenetic distribution and virulence potential
(2020)C. difficile induces antibiotic-associated diarrhea due to the action of two secreted toxins, TcdA and TcdB. A considerable range of virulence among C. difficile strains has been widely reported. During a hospital outbreak, ... -
Toxin B Variants from Clostridium difficile Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors
(2019)Clostridium difficile induces antibiotic-associated diarrhea due to the release of toxin A (TcdA) and toxin B (TcdB), the latter being its main virulence factor. The epidemic strain NAP1/027 has an increased virulence ... -
El uso de animales de experimentación en la investigación biomédica en Costa Rica
(Acta Médica Costarricense 52(3), 2010-07)El progreso en la investigación médica y biológica ha dependido en gran medida del uso de animales experimentales Dada la importancia que históricamente han tenido los animales como reactivos biológicos en la investigación ...