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Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom

Gutiérrez, José María; León Montero, Guillermo; Rojas Céspedes, Gustavo; Lomonte, Bruno; Rucavado Romero, Alexandra; Chaves Mora, Fernando (1998-11)

Local tissue damage represents a serious consequence of Bothrops asper envenomations. It encompasses a complex series of alterations, including myonecrosis, dermonecrosis, hemorrhage and edema. Due to its rapid development ...

Inhibition by CaNa2EDTA of local tissue damage induced by Bothrops asper (terciopelo) venom: Application in horse immunization for antivenom production

León Montero, Guillermo; Estrada Umaña, Ricardo; Chaves Mora, Fernando; Rojas Céspedes, Gustavo; Ovadia, Michael; Gutiérrez, José María (1998-03-26)

The ability of the chelating agent CaNa2EDTA to inhibit local tissue damage induced by Bothrops asper venom was studied in mice and in horses used for polyvalent (Crotalinae) antivenom production. CaNa2EDTA was devoid of ...