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An alternative in vitro method for testing the potency of the polyvalent antivenom produced in Costa Rica
(1988)
The ability of several batches of polyvalent antivenom to neutralize indirect hemolytic activity of Bothrops asper venom was studied using a sensitive plate test. All samples of antivenom tested effectively neutralized ...
Antibody neutralization of a myotoxin from the venom of Bothrops asper (terciopelo)
(1987)
Neutralization of biological activities of B. asper myotoxin by a monospecific anti-myotoxin rabbit serum and polyvalent antivenom was studied. Both antisera neutralized myotoxic, phospholipase A and lethal activities of ...
Comparative study on coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenom
(1989)
The coagulant, defibrinating, fibrino lytic and fibrinogenolytic activities of venoms from ten species of Costa Rican crotaline snakes were studied, together with the neutralization of these effects by a polyvalent antivenom. ...
Histopathological and biochemical alterations induced by intramuscular injection of Bothrops asper (terciopelo) venom in mice
(1989)
The local and systemic pathological changes induced by an i.m. injection of 100 micrograms of Bothrops asper venom in mice were studied histologically and by following the changes in serum levels of enzymes, proteins, ATP ...
Ability of a polyvalent antivenom to neutralize the venom of Lachesis muta melanocephala, a new Costa Rican subspecies of the bushmaster
(1987)
Several toxic and enzymatic activities of the venom of L. m. melanocephala were studied. This venom has many similarities with that of L. m. stenophrys, although there are quantitative differences in venom activities, as ...
Inflammatory infiltrate in skeletal muscle injected with Bothrops asper venom
(1986)
The time-course and composition of inflammatory infiltrate in mouse gastrocnemius injected with Bothrops asper venom was studied. The venom induced myonecrosis, and a prominent decrease in muscle levels of creatine kinase ...
Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom
(1985)
The polyvalent antivenom produced at the Instituto Clodomiro Picado, Costa Rica, was tested for its capacity to neutralize proteolytic and hemorrhagic activities of ten Costa Rican crotaline venoms. In experiments with ...
Comparative study of the edema-forming activity of Costa Rican snake venoms and its neutralization by a polyvalent antivenom
(1986)
The edema-forming activity of eight Costa Rican crotaline snake venoms and its neutralization by a polyvalent antivenom were studied using the mouse footpad test. All of the venoms induced edema, the highest activity being ...
Pharmacological activities of a toxic phospholipase A isolated from the venom of the snake Bothrops asper
(1986)
A toxic phospholipase A was isolated from the venom of Bothrops asper. It induced skeletal muscle damage, anticoagulant effects and edema in the foot pad. The toxin had an intravenous LD50 of 95 micrograms/16-18 g mouse ...