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Antivenomics of Atropoides mexicanus and Atropoides picadoi snake venoms: Relationship to the neutralization of toxic and enzymatic activities
(2010-09-30)
Viperid snakes of the genus Atropoides are distributed in Mexico and Central America and, owing to their size and venom yield, are capable of provoking severe envenomings in humans. This study evaluated, using an ‘antivenomics’ ...
Characterization of a novel snake venom component: Kazal-type inhibitor-like protein from the arboreal pitviper Bothriechis schlegelii
(2016-06)
Snake venoms are composed mainly of a mixture of proteins and peptides. Notably, all snake venom toxins have been assigned to a small number of protein families. Proteomic studies on snake venoms have recently identified ...
Venomics of new world pit vipers: genus-wide comparisons of venom proteomes across Agkistrodon
(Journal of Proteomics vol 96, p.103-116, 2014-01-16)
Wereport a genus-wide comparison of venomproteomevariation acrossNewWorld pit vipers in the genus Agkistrodon. Despite the wide variety of habitats occupied by this genus and that all its taxa feed on diverse species of ...
Immunological profile of antivenoms: preclinical analysis of the efficacy of a polyspecific antivenom through antivenomics and neutralization assays
(En prensa, 2014-02-28)
Parenteral administration of animal-derived antivenoms constitutes the mainstay in the
treatment of snakebite envenomings. Despite the fact that this therapy has been available for over a century, the detailed understanding ...
Snake venomics of crotalus tigris: the minimalist toxin arsenal of the deadliest neartic rattlesnake venom: evolutionary clues for generating a pan-specific antivenom against crotalid type II venoms
(Journal of Proteome Research 11(2): 1382–1390, 2012-02-03)
We report the proteomic and antivenomic characterization of Crotalus tigris venom. This venom exhibits the highest lethality for mice among rattlesnakes and the simplest toxin proteome reported to date. The venom proteome ...
Venomous snakes of Costa Rica: biological and medical implications of their venom proteomic profiles analyzed through the strategy of snake venomics
(Journal of Proteomics XX (2014) XXX – XXX, Available online 24 February 2014, 2014-02-24)
In spite of its small territory of ~50,000 km2, Costa Rica harbors a remarkably rich biodiversity. Its herpetofauna includes 138 species of snakes, of which sixteen pit vipers (family Viperidae, subfamily Crotalinae), five ...
Omics Meets Biology: Application to the Design and Preclinical Assessment of Antivenoms
(Toxins vol.6:3388-3405, 2014-12-15)
Snakebite envenoming represents a neglected tropical disease that has a heavy public health impact worldwide, mostly affecting poor people involved in agricultural activities in Africa, Asia, Latin America and Oceania. A ...
Snake Venomics of Central American Pitvipers: Clues for Rationalizing the Distinct Envenomation Profiles of Atropoides nummifer and Atropoides picadoi
(2008)
We report the proteomic characterization of the Central American pitvipers Atropoides nummifer and
Atropoides picadoi. The crude venoms were fractionated by reverse-phase high-performance liquid
chromatography (HPLC), ...
Snake Venomics and Antivenomics of the Arboreal Neotropical Pitvipers Bothriechis lateralis and Bothriechis schlegelii
(2008-04-30)
We report the comparative proteomic characterization of the venoms of two related neotropical arboreal pitvipers from Costa Rica of the genus Bothriechis, B. lateralis (side-striped palm pit viper) and B. schlegelii (eyelash ...
Isolation and characterization of four medium-size disintegrins from the venoms of Central American viperid snakes of the genera Atropoides, Bothrops, Cerrophidion and Crotalus
(2014-12)
Four disintegrins were isolated from the venoms of the Central American viperid snakes Atropoides mexicanus (atropoimin), Bothrops asper (bothrasperin), Cerrophidion sasai (sasaimin), and Crotalus simus (simusmin). ...