Buscar
Mostrando ítems 1-10 de 363
Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism
(2009-11-02)
The venom proteomes of Bothrops atrox from Colombia, Brazil, Ecuador, and Perú were characterized using venomic and antivenomic strategies. Our results evidence the existence of two geographically differentiated venom ...
Effect of various Viperidae and Crotalidae snake venoms on endothelial cells in vitro
(1994)
The effect of various crotalid and viperid venoms at 10, 50 and 100 μg/ml was examined on bovine and murine endothelial cells in vitro. The venoms caused the cells to lose their processes, leading to the appearance of ...
Stable production of recombinant SARS-CoV-2 receptor-binding domain in mammalian cells with co-expression of a fluorescent reporter and its validation as antigenic target for COVID-19 serology testing
(2023-01)
SARS-CoV-2 receptor binding domain (RBD) recognizes the angiotensin converting enzyme 2 (ACE2) receptor in host cells that enables infection. Due to its antigenic specificity, RBD production is important for development ...
Myonecrosis induced in mice by a basic myotoxin isolated from the venom of the snake Bothrops nummifer (jumping viper) from Costa Rica
(1989)
The mode of action of a basic myotoxin isolated from Bothrops nummifer venom was studied. This myotoxin is a basic polypeptide of 13,000 mol.wt, with a high content of lysine and aspartate, as well as of hydrophobic amino ...
A Lys49 Phospholipase A2, Isolated from Bothrops asper Snake Venom, Induces Lipid Droplet Formation in Macrophages Which Depends on Distinct Signaling Pathways and the C-Terminal Region
(2013)
MT-II, a Lys49PLA2 homologue devoid of catalytic activity from B. asper venom, stimulates inflammatory events in macrophages. We investigated the ability of MT-II to induce formation of lipid droplets (LDs), key elements ...
Niveles de inmunoglobulinas séricas (IgG, IgA e IgM) en adultos jóvenes sanos, por el método de inmunodifusión radial
(1985)
Se determinó la concentración de IgG, IgA, e IgM en el suero de 49 estudiantes universitarios normales, de 18 a 25 años. Para esto se empleó el método de inmunodifusión radial, en placas comerciales. Los resultados fueron ...
Snake Venomics and Antivenomics of the Arboreal Neotropical Pitvipers Bothriechis lateralis and Bothriechis schlegelii
(2008-04-30)
We report the comparative proteomic characterization of the venoms of two related neotropical arboreal pitvipers from Costa Rica of the genus Bothriechis, B. lateralis (side-striped palm pit viper) and B. schlegelii (eyelash ...
Snake venom Lys49 myotoxins: from phospholipases A2 to non-enzymatic membrane disruptors
(2012-09)
Snake venoms often contain toxins that cause a rapid necrosis of skeletal muscle fibers,
referred to as myotoxins. The most common among them are phospholipases A2 (PLA2s),
enzymes that have two independent evolutionary ...
Venom of the neotropical rattlesnake, Crotalus culminatus: Intraspecific variation, neutralization by antivenoms, and immunogenicity in rabbits
(2024)
Crotalus culminatus is a medically significant species of rattlesnake in Mexico [1]. While the proteomic composition of its venom has been previously reported for both juvenile and adult specimens, there has been limited ...
Innovative immunization strategies for antivenom development
(2018)
Snakes, scorpions, and spiders are venomous animals that pose a threat to human
health, and severe envenomings from the bites or stings of these animals must be treated with
antivenom. Current antivenoms are based on ...