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Mostrando ítems 31-40 de 363
Porcentaje y cifra absoluta de linfocitos T en sangre periférica por el método de rosetas E: estudio de cuarenta adultos sanos
(1985)
Se realizó la determinación del porcentaje y cifra absoluta de linfocitos T en sangre periférica a un grupo de 40 adultos sanos costarricenses, seleccionados de un grupo inicial de 58 voluntarios. Se utilizó un método de ...
Catalytically inactive phospholipase A2 homologue binds to vascular endothelial growth factor receptor-2 via C-terminal loop region
(2008)
VEGF (vascular endothelial growth factor) regulates neovascularization
through binding to its receptorKDR(kinase insert domaincontaining
receptor; VEGF receptor-2). We recently identified
a catalytically inactive PLA2 ...
Venom of the Coral Snake Micrurus clarki: Proteomic Profile, Toxicity, Immunological Cross-Neutralization, and Characterization of a Three-Finger Toxin
(2016)
Micrurus clarki is an uncommon coral snake distributed from the Southeastern Pacific of Costa Rica to Western Colombia, for which no information on its venom could be found in the literature. Using a 'venomics' approach, ...
Novel snakebite therapeutics must be tested in appropriate rescue models to robustly assess their preclinical efficacy
(2020)
In the field of antivenom research, development, and manufacture, it is often advised to follow the World Health Organization’s (WHO) guidelines for the production, control, and regulation of snake antivenom immunoglobulins, ...
Broad cytolytic specificity of myotoxin II, a lysine-49 phospholipase A2 of Bothrops asper snake venom
(1994)
The cytotoxic activity of Bothrops asper myotoxin II, a lysine-49 phospholipase A2 isoform, on different cell types in culture, was investigated. Myotoxin II caused a dose-dependent cytolytic effect on all cell types tested, ...
Antibodies to Helicobacter pylori in dyspeptic patients, asymptomatic adults, and children from Costa Rica
(1995-06-30)
An enzyme immunoassay for the detection of serum IgG antibodies to H. pylori whole bacterial sonicate was used in a study of dyspeptic adult patients (n=165), apparently healthy blood donors (n=154), and children (n = 66) ...
A catalytically-inactive snake venom Lys49 phospholipase A2 homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages
(2013-05-15)
The effects of a snakevenom Lys-49phospholipaseA2 (PLA2) homolog named MT-II,devoid of enzymatic activity, on the biosynthesis of prostaglandins and protein expression of cyclooxygenase-2(COX-2) and signaling pathways ...
Primary structures and partial toxicological characterization of two phospholipases A2 from Micrurus mipartitus and Micrurus dumerilii coral snake venoms
(2017-06)
Snake venom phospholipases A2 (PLA2) share high sequence identities and a conserved structural scaffold, but show important functional differences. Only a few PLA2s have been purified and characterized from coral snake ...
Peligros de los falsos positivos en la determinación de gonadotropina coriónica
(2001)
Los expertos del Servicio de Referencia para hCG (hormona gonadotropina coriónica humana) de los Estados Unidos de América, han llamado la atención de los laboratorios que realizan la determinación de esta hormona, para ...
Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants
(2003-05)
The ability of Lys49 and Asp49 phospholipases A2 (PLA2), from Bothrops asper snake venom, to cause hyperalgesia was investigated in rats, using the paw pressure test. Intraplantar injection of both toxins (5–20 μg/paw) ...