• Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction 

  Cornelis, Marilyn C.; El-Sohemy, Ahmed; Campos Núñez, Hannia (2004)

  There is growing evidence that DNA damage caused by mutagens found in tobacco smoke may contribute to the development of coronary heart disease (CHD). In order to bind to DNA many mutagens require metabolic activation by ...

• Genetic variants of the lipoprotein lipase gene and myocardial infarction in the Central Valley of Costa Rica 

  Yang, Yadong; Ruiz Narváez, Edward A.; Niu, Tianhua; Xu, Xiping; Campos Núñez, Hannia (2004)

  To assess common variants of the LPL gene that could influence susceptibility to myocardial infarction (MI), we assessed three functional single-nucleotide polymorphisms (SNPs), D9N, N291S, and S447X, in 1,321 survivors ...

• Editorial: limitações das leituras de temperatura temporal (testa) como método de triagem para COVID-19 

  Aragón Vargas, Luis Fernando (2020-06-25)

  Com o avanço contínuo da pandemia de Covid-19, muitos países estão em processo de reabertura de escolas, igrejas e empresas. Em um esforço para rastrear indivíduos potencialmente infectados, a temperatura da artéria temporal ...

• Voz experta: El problema de usar las mediciones de la temperatura corporal en la frente como método de tamizaje para el COVID-19 

  Aragón Vargas, Luis Fernando (2020-06-25)

  En estos tiempos de la pandemia por la enfermedad COVID-19, muchos países han iniciado el proceso de reapertura de escuelas, iglesias y negocios. Para limitar el riesgo de contagio, una de las medidas consiste en detectar ...

• Intake of trans fatty acids and low-density lipoprotein size in a Costa Rican population 

  Kyung Kim, Mi; Campos Núñez, Hannia (2003)

  Intervention studies show that dietary composition altered low-density lipoprotein (LDL) particle size, but population studies are scarce, and the potential effects of trans fatty acids (FA) on LDL size are unknown. Trans ...

• High 18:2 trans fatty acids are associated with increased risk of nonfatal acute myocardial infarction in Costa Rican adults 

  Baylin, Ana; Kabagambe, Edmond K.; Ascherio, Alberto; Spiegelman, Donna; Campos Núñez, Hannia (2003)

  Trans-fatty acid intake is associated with coronary heart disease (CHD), but the atherogenic potential of individual trans-fatty acids (FA) from partially hydrogenated oils (18:1 and 18:2) or meat and dairy products (16:1 ...

• APOC3/A5 haplotypes, lipid levels, and risk of myocardial infarction in the Central Valley of Costa Rica 

  Ruiz Narváez, Edward A.; Yang, Yadong; Nakanishi, Yukiko; Kirchdorfer, Jill; Campos Núñez, Hannia (2005)

  Genetic variation in the APOC3 and APOA5 genes has been associated with plasma triglyceride concentrations and may affect the risk of myocardial infarction (MI). To assess whether APOC3/A5 haplotypes are associated with ...

• GSTT1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction 

  Cornelis, Marilyn C.; El-Sohemy, Ahmed; Campos Núñez, Hannia (2007)

  Background: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with protection against components of the metabolic syndrome, but the role of α-linolenic acid (ALA), the metabolic precursor of EPA and ...

• Does genetic variation in the Δ6-desaturase promoter modify the association between α-linolenic acid and the prevalence of metabolic syndrome? 

  Truong, Hong; DiBello, Julia R.; Ruiz Narváez, Edward A.; Kraft, Peter; Campos Núñez, Hannia; Baylin, Ana (2009)

  Background: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with protection against components of the metabolic syndrome, but the role of α-linolenic acid (ALA), the metabolic precursor of EPA and ...

• Conjugated linoleic acid in adipose tissue and risk of myocardial infarction 

  Smit, Liesbeth A.; Baylin, Ana; Campos Núñez, Hannia (2010)

  Despite the high saturated fat content of dairy products, no clear association between dairy product intake and risk of myocardial infarction (MI) has been observed. Dairy products are the main source of conjugated linoleic ...

• Planificación familiar 

  Rosero Bixby, Luis (1994)

  En este capítulo se presentan los resultados de la encuesta referentes al conocimiento, difusión y uso de la planificación familiar en Costa Rica. En el análisis se aborda el uso en el pasado, la adopción por vez primera ...

• Association between hepatic lipase -514 C/T promoter polymorphism and myocardial infarction is modified by history of hypercholesterolemia and waist circumference 

  Baylin, Ana; Ruiz Narváez, Edward A.; Jensen, Majken K.; Rimm, Eric B.; Campos Núñez, Hannia (2009)

  Background and aims: To examine whether the association between the 514 C/T polymorphism of the hepatic lipase gene and myocardial infarction (MI) is modified by history of hypercholesterolemia and increased waist ...

• Adipose tissue biomarkers of fatty acid intake 

  Baylin, Ana; Kabagambe, Edmond K.; Siles Díaz, Xinia; Campos Núñez, Hannia (2002)

  The use of biomarkers to assess dietary intake has increased dramatically in the past few years (1-7). Biomarkers may provide a more accurate and objective measure of long-term intake than dietary questionnaires provide ...

• Immune effects of mesenchymal stem cells: Implications for Charcot–Marie–Tooth disease 

  Leal Esquivel, Alejandro; Ichim, Thomas E.; Marleau, Annette M.; Lara, Fabián; Kaushal, Shalesh; Riordan, Neil H. (2008-07)

  Mesenchymal stem cell (MSC) therapy is the most clinically advanced form of cell therapy, second to hematopoietic stem cell transplants. To date, MSC have been used for immune modulation in conditions such as Graft Versus ...

• Microglial recruitment of IL-1β-producing monocytes to brain endothelium causes stress-induced anxiety 

  McKim, Daniel B.; Weber, Michael D.; Niraula, Anzela; Sawicki, Caroline M.; Liu, X.; Jarrett, Brant L.; Ramírez Chan, Karol Gabriela; Wang, Yufen; Roeth, R. M.; Sucaldito, A. D.; Sobol, Carly G.; Quan, Ning; Sheridan, John F.; Godbout, Jonathan P. (2017-04-04)

  Psychosocial stress contributes to the development of anxiety and depression. Recent clinical studies have reported increased inflammatory leukocytes in circulation of individuals with stress-related psychiatric disorders. ...

• Enfermedades de transmisión sexual 

  Ickowicz Goldstein, Diana; Rocha Palma, Milania Evelyn (2004-02)

  Las enfermedades de transmisión sexual (ETS) representan un problema de salud pública, que afecta a un porcentaje de la población tanto a nivel mundial como a nivel nacional. A pesar de que las ciertas enfermedades de ...

• In Vitro Antioxidant and Antimicrobial Activities of Ethanolic Extracts from Whole Plants of Three Impatiens Species (Balsaminaceae) (documento borrador) 

  Molzon, Justina; Bolaños, Ricardo; Storpirtis, Silvia; Pound, Norman; Gordon, John; Pereira, Conrad; Concha, Ana María; Milla, Pamela; Pezoa Reyes, Regina; Rodríguez, Marcela; Fonseca González, Lidiette; Brown, Eugene; Satvchansky, Salomon; Williams, Roger; Goncalves, Irene; Giarcovich, Silvia; Marquez, Loreta (2005-03)

  Objetivos Este documento discute la comercialización de productos farmacéuticos que son terapéuticamente equivalentes, y por lo tanto intercambiables pero son producidos por diferentes fabricantes. Declaración de ...

• Dietary patterns and risk of nonfatal acute myocardial infarction in Costa Rican adults 

  Martínez Ortiz, José Antonio; Fung, T. T.; Baylin, Ana; Hu, F. B.; Campos Núñez, Hannia (2006)

  Cardiovascular disease (CVD) has become an important public health problem in transition countries in Latin America (Medina and Kaempffer, 2000; Cubillos-Garzón et al., 2004; Ventura and Mehra, 2004; World HealthOrganization, ...

• Homozygous Mutation in GPT2 Associated with Nonsyndromic Intellectual Disability in a Consanguineous Family from Costa Rica 

  Lobo Prada, Tanya; Sticht, Heinrich; Bogantes Ledezma, Sixto; Ekici, Arif; Uebe, Steffen; Reis, André; Leal Esquivel, Alejandro (2016)

  Intellectual disability is a highly heterogeneous disease that affects the central nervous system and impairs patients’ ability to function independently. Despite multiples genes involved in the etiology of disease, most ...

• GABAergic modulation with classical benzodiazepines prevent stress-induced neuro-immune dysregulation and behavioral alterations 

  Ramírez Chan, Karol Gabriela; Niraula, Anzela; Sheridan, John F. (2016)

  Objective: Psychosocial stress is associated with altered immunity, anxiety, and depression. Repeated social defeat (RSD), a model of social stress, triggers egress of inflammatory myeloid progenitor cells (MPCs; ...

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