• Sobrevida y calidad de vida de los pacientes con cardiopatía isquémica egresados de una Unidad de Cuidados Intensivos de tercer nivel 

  Barrantes Morales, Faride; Salas Segura, Donato A. (2016-02)

  Justificación: La sobrevida y la calidad de vida los pacientes que son egresados de las unidades de cuidado intensivo se ha vuelto una preocupación frecuente por la alta incidencia de ...

• Production and partial characterization of monoclonal antibodies to Bothrops asper (terciopelo) myotoxin 

  Lomonte, Bruno; Kahan, Lawrence (1988)

  Seven murine monoclonal antibodies against Bothrops aspen myotoxin were produced and partially characterized. They revealed the presence of at least four cross-reacting basic components in crude venom, with a common subunit ...

• A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo) 

  Lomonte, Bruno; Gutiérrez, José María (1989)

  A new muscle damaging toxin, myotoxin II, was purified from the venom of Bothrops asper by ion-exchange chromatography on CMSephadex C-25. The toxin is a dimeric, basic protein with a monomer mol.wt of 13,341, according ...

• El suero antiofídico polivalente producido en Costa Rica: Estabilidad y capacidad neutralizante 

  Gutiérrez, José María; Lomonte, Bruno; Rojas Céspedes, Gustavo; Gené, José Antonio; Chaves, Fernando; Estrada Umaña, Ricardo; Alvarado, Jorge; Rojas Umaña, Ermila; Robles, Abel (1988)

  En este trabajo se revisan y discuten una serie de aspectos relativos a la producción, estabilidad y capacidad neutralizante del suero antiofídico polivalente producido por el Instituto Clodomiro Picado. Este suero ...

• Efecto del suero antiofídico sobre la actividad hemolítica del complemento humano (in vitro) y de conejo (in vitro e in vivo). 

  Montero Fernández, Jenny; Trejos Herrera, Marianela; Lomonte, Bruno (1989)

  En el presente trabajo se investigó el efecto del suero antiofídico polivalente, producido en Costa Rica, sobre la actividad hemolítica (CH50) del complemento sérico humano (in vitro) y de conejo (in vitro e in vivo). ...

• El suero de neonatos de Clelia clelia (Serpentes: Colubridae) neutraliza la acción hemorrágica del veneno de Bothrops asper (Serpentes: Viperidae). 

  Lomonte, Bruno; Cerdas Fallas, Luis; Solórzano López, Alejandro; Martínez, Soledad (1989)

  The ability of serum from nine newbom specimens of Clelia clelia (Colubridae) to neutralize hernorrhagic action of Bothrops asper venom was tested. All serum samples neutralized completely the hernorrhagic effect of the ...

• A MLST Clade 2 Clostridium difficile strain with a variant TcdB induces severe inflammatory and oxidative response associated with mucosal disruption 

  Leite Costa, Cecília; López Ureña, Diana; de Oliveira Assis, Thiago; Ribeiro, Ronaldo A.; Silveira Silva, Rodrigo Otavio; Rupnik, Maja; Wilcox, Mark H.; Fiorini de Carvalho, Alex; Oliveira do Carmo, Anderson; Abalen Martins Dias, Adriana; Barreto Mano de Carvalho, Cibele; Chaves Olarte, Esteban; Rodríguez Sánchez, César; Quesada Gómez, Carlos; de Castro Brito, Gerly Anne (2016-08)

  The epidemiology of Clostridium difficile infections is highly dynamic as new strains continue to emerge worldwide. Here we present a detailed analysis of a new C. difficile strain (ICC-45) recovered from a cancer patient ...

• A biocomputational platform for the automated construction of large-scale mathematical models of miRNA-transcription factor networks for studies on gene dosage compensation 

  Acón, Man Sai; Siles Canales, Francisco; Mora Rodríguez, Rodrigo (2016-11-09)

  Cancer complexity and resistance is mediated by cell-to-cell heterogeneity, which is the consequence of the enormous instability of its genetic material. It is unknown how cancer cells are able to withstand the effects ...

• Arboviral encephalitis in Costa Rican horses: 2009-2016 

  Jiménez Rojas, César; Romero, Mario; Piche, Marta; Baldi, Mario; Alfaro Alarcón, Alejandro; Chaves, Andrea; Morales, J.; León Rodriguez, Bernal; Hutter, Sabine Elisabeth; Corrales Aguilar, Eugenia (2016-12)

  Arbovirus of the genus Alphavirus and Flavivirus can cause febrile illness and sometimes neurological disease in both humans and animals. West Nile Virus (WNV), Eastern Equine Encephalitis Virus (EEEV), Western Equine ...

• Highly individual patterns of virus‑immune IgG effector responses in humans 

  Corrales Aguilar, Eugenia; Trilling, Mirko; Reinhard, Henrike; Falcone, Valeria; Zimmermann, Albert; Adams, Ortwin; Santibanez, Sabine; Hengel, Hartmut (2016-05-18)

  t IgG responses are fundamental to adaptive immunity and document immunological memory of previous pathogen encounter. While specific antigen recognition is mediated by the variable F(ab′)2 domain of IgG, various effector ...

• Molecular Characterization of Two Major Dengue Outbreaks in Costa Rica 

  Soto Garita, Claudio; Somogyi Pérez, Teresa; Vicente Santos, Amanda; Corrales Aguilar, Eugenia (2016-07)

  Dengue virus (DENV) (Flavivirus, Flaviviridae) is a reemerging arthropod-borne virus with a worldwide circulation, transmitted mainly by Aedes aegypti and Aedes albopictus mosquitoes. Since the first detection of its ...

• The need for an integrated approach in confronting snakebite envenoming in Latin America: the relevance of endogenous scientific and technological research 

  Gutíerrez, José María; Pereañez, Jaime Andrés (2016)

  Snakebite envenomings constitute a serious public health problem on a global level, especially in Africa, Asia and Latin America. In our Latin American region, it is estimated that at least 70,000 snakebite cases occur ...

• Development of a chicken-derived antivenom against the taipan snake (Oxyuranus scutellatus) venom and comparison with an equine antivenom 

  Navarro, Diego; Vargas Arroyo, Mariángela; Herrera Vega, María; Segura Ruiz, Álvaro; Gómez Argüello, Aarón; Villalta, Mauren; Ramírez Arguedas, Nils Antonio; Williams, David J.; Gutiérrez, José María; León Montero, Guillermo (2016-09-15)

  A chicken-derived antivenom (ChDAv) towards taipan snake (Oxyuranus scutellatus) venom was produced by purifying anti-taipan IgY from egg yolks of hens immunized with taipan venom. The productivity, antivenomic profile, ...

• El virus del Zika 

  Corrales Aguilar, Eugenia; Soto Garita, Claudio (2016-01)

  El virus del Zika es un arbovirus emergente. Se transmite por medio de los mosquitos del género Aedes. Fue descrito por primera vez en mosquitos y monos del bosque Zika en Uganda, en 1947; posteriormente, en seres humanos ...

• Molecular detection of Clostridium difficile on inert surfaces from a Costa Rican hospital during and after an outbreak 

  Morales, Luisa; Rodríguez Sánchez, César; Gamboa Coronado, María del Mar (2016-12-01)

  Background: Hospital transmission of Clostridium difficile is fostered by contamination of surfaces and medical equipment with spores highly resistant to disinfectants and regular cleaning procedures. Despite the outbreaks ...

• Evaluación de la resistencia a insecticidas en cepas de Aedes aegypti (Diptera Culicidae) de la Región Caribe de Costa Rica 

  Calderón Arguedas, Ólger; Troyo Rodríguez, Adriana (2016-01)

  Introducción: el dengue y chikungunya son virosis antroponóticas transmitidas por Aedes aegypti que afectan extensas áreas del continente americano incluyendo Costa Rica. La reciente introducción del virus Zika representa ...

• Exposure of dogs to spotted fever group rickettsiae in urban sites associated with human rickettsioses in Costa Rica 

  Moreira Soto, Andrés; Carranza, Marco V; Taylor Castillo, Lizeth; Calderón Arguedas, Ólger; Hun O, Laya; Troyo Rodríguez, Adriana (2016-07)

  The zoonotic transmission cycles of Rickettsia rickettsii and other spotted fever group (SFG) rickettsiae in Latin America have usually been associated with rural or sylvatic environments, although domestic dogs can be ...

• Prevalencia de fasciolosis en bovinos de Costa Rica (2014). Comparación de cuatro técnicas diagnósticas 

  Rojas Araya, Diana; Montero, A.; León, D.; Romero Zúñiga, Juan José (2016)

  Se realizó un estudio transversal con el objetivo de determinar la prevalencia de fasciolosis en bovinos sacrificados en mataderos de Costa Rica y comparar cuatro técnicas diagnósticas disponibles (inspección macroscópica ...

• Biopiracy of natural products and good bioprospecting practice 

  Efferth, Thomas; Banerjee, Mita; Paul, Norbert W.; Abdelfatah, Sara; Arend, Joachim; Elhassan, Gihan; Hamdoun, Sami; Hamm, Rebecca; Hong, Chunlan; Kadioglu, Onat; Naß, Janine; Ochwangi, Dominic; Ooko, Edna; Ozenver, Nadire; Saeed, Mohamed E. M.; Schneider, Mathias; Seo, Ean-Jeong; Wu, Ching-Fen; Yan, Ge; Zeino, Maen; Zhao, Qiaoli; Abu Darwish, Mohammad S.; Andersch, Kai; Alexie, Gladys; Bessarab, Dawn; Bhakta Guha, Dipita; Bolzani, Vanderlan; Dapat, Else; Donenko, Fedor V.; Efferth, Monika; Greten, Henry J.; Gunatilaka, Leslie; Hussein, Ahmed A.; Karadeniz, Asuman; Khalid, Hassan E.; Kuete, Victor; Lee, Ik-Soo; Liu, Liang; Midiwo, Jacob; Mora Rodríguez, Rodrigo; Nakagawa, Hiroshi; Ngassapa, Olipa; Noysang, Chanai; Omosa, Leonida K.; Roland, Fred Hwiemtun; Shahat, Abdelaaty A.; Saab, Antoine; Saeed, Elfatih M.; Shan, Letian; Titinchi, Salam J. J. (2016-02-15)

  Background: Biopiracy mainly focuses on the use of biological resources and/or knowledge of indigenous tribes or communities without allowing them to share the revenues generated out of economic exploitation or other ...

• Detection of rickettsiae in fleas and ticks from areas of Costa Rica with history of spotted fever group rickettsioses 

  Troyo Rodríguez, Adriana; Moreira Soto, Rolando; Calderón Arguedas, Ólger; Mata Somarribas, Carlos; Ortiz Tello, Jusara; Barbieri, Amália R. M.; Avendaño López, Adrián; Vargas Castro, Luis E.; Labruna, Marcelo B.; Hun O, Laya; Taylor Castillo, Lizeth (2016-10)

  Outbreaks of spotted fevers have been reported in Costa Rica since the 1950s, although vectors responsible for transmission to humans have not been directly identified. In this study, species of Rickettsia were detected ...

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