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Recent Submissions
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Análisis de la concordancia en torno a la voluntad anticipada emitida por los pacientes de la clínica de la memoria del Hospital Nacional de Geriatría y Gerontología, con diagnóstico de deterioro cognitivo leve, entre junio de 2018 y junio de 2019, Costa Rica
(2020-01-29)Existe un reconocido aumento en la prevalencia de las enfermedades neurodegenerativas como la demencia. Una característica de los síndromes demenciales es la pérdida paulatina, incluso en etapas relativamente tempranas ... -
Enzymatic labelling of venom phospholipase A2 toxins
(2019)Almost all animal venoms contain secretory phospholipases A2 (PLA2s), 14 kDa disulfide-rich enzymes that hydrolyze membrane phospholipids at the sn-2 position, releasing lysophospholipids and fatty acids. These proteins, ... -
Novel three-finger toxins from Micrurus dumerilii and Micrurus mipartitus coral snake venoms: phylogenetic relationships and characterization of Clarkitoxin-I-Mdum
(2019)Micrurus mipartitus and M. dumerilii are the most medically important coral snakes in Colombia. Proteomic characterization of their venoms has previously shown that proteins of the three-finger toxin (3FTx) family ... -
A secreted phospholipase A2 induces formation of smooth muscle foam cells which trans-differentiate to macrophage-like state
(2019)Vascular smooth muscle cells (VSMCs) loaded with lipid droplets (LDs) are markers of atherosclerosis. In this disease, inflammatory Group IIA-secreted phospholipase A2s (GIIA sPLA2s) are highly expressed in VSMCs, but ... -
Transfección mediante vehículos génicos basados enhidroxiapatita: eficacia y efectos sobre el tráfico intracelular
(2025)La hidroxiapatita (HAp), Ca10(PO4)6(OH)2, es un mineral miembro de las apatitas con una razón Ca/P de 1,67. Es el principal componente mineral de los huesos en los vertebrados y posee una serie de características de interés ... -
Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species
(2019)Antivenoms are fundamental in the therapy for snakebites. In elapid venoms, there are toxins, e.g. short-chain α-neurotoxins, which are quite abundant, highly toxic, and consequently play a major role in envenomation ... -
Isolation of two basic phospholipases A2 from Bothrops diporus snake venom: comparative characterization and synergism between Asp49 and Lys49 variants
(2019)Bothrops diporus, previously considered a subspecies of the B. neuwiedi complex, is a medically relevant viperid in Northeastern Argentina. The venom of this species causes local tissue damage characterized by ... -
Three-finger toxins from the venom of Micrurus tschudii (desert coral snake): isolation and characterization of tschuditoxin-I
(2019)Venoms from Micrurus (New World coral snakes) display potent peripheral neurotoxicity which may cause death by respiratory paralysis, yet many are poorly or not characterized. The major venom components of coral snakes are ... -
New insights into the phylogeographic distribution of the 3FTx/PLA2 venom dichotomy across genus Micrurus in South America
(2019)Micrurus is a monophyletic genus of venomous coral snakes of the family Elapidae. The ~80 recognized species within this genus are endemic to the Americas, and are distributed from southeastern United States to ... -
Plan de seguridad del agua de la Asada Las Vueltas, Parrita, Puntarenas, 2019.
(2020)Este estudio presenta la elaboración de un Plan de Seguridad del Agua de la ASADA Las Vueltas, de acuerdo con lo establecido en la cuarta guía de calidad del agua, de la Organización Mundial de la Salud. Para el cumplimiento ... -
Enfermedad de Alzheimer en Costa Rica. Una realidad poco investigada
(2018)El incremento de la población adulta mayor en nuestro país ha generado una mayor prevalencia de varias enfermedades, entre ellas las de tipo cognitivo como lo es la Enfermedad de Alzheimer (EA). El propósito de este ... -
Proteomic profiling, functional characterization, and immunoneutralization of the venom of Porthidium porrasi, a pitviper endemic to Costa Rica
(2019)The genus Porthidium includes nine pitviper species inhabiting Mexico, Central America, and northern South America. Porthidium porrasi is a species endemic to the Southwest of Costa Rica, for which no information on ... -
First look into the venom of Roatan Island´s critically endangered coral snake Micrurus ruatanus: proteomic characterization, toxicity, immunorecognition and neutralization by an antivenom
(2019)A proteomic and toxicological study of the venom from one specimen of Micrurus ruatanus, a critically endangered coral snake species endemic to Roatan Island, Honduras, was carried out. Immunorecognition and neutralization ... -
Biochemical characterization of the venom of Central American scorpion Didymocentrus krausi Francke, 1978 (Diplocentridae) and its toxic effects in vivo and in vitro
(2019)non-buthid venoms, for which knowledge is scarce. In this work, we characterized the venom of a Diplocentridae species, Didymocentrus krausi, a small fossorial scorpion that inhabits the Tropical Dry Forest of Central ... -
Venom characterization of the three species of Ophryacus and proteomic profiling of O. sphenophrys unveils Sphenotoxin, a novel Crotoxin-like heterodimeric β-neurotoxin
(2019)Venoms of the three species of Ophryacus (O. sphenophrys, O. smaragdinus, and O. undulatus), a viperid genus endemic to Mexico, were analyzed for the first time in the present work. The three venoms lacked procoagulant ... -
Cloning, purification and characterization of nigrelysin, a novel actinoporin from the sea anemone Anthopleura nigrescens
(2019)Actinoporins constitute a unique class of pore-forming toxins found in sea anemones that being secreted as soluble monomers are able to bind and permeabilize membranes leading to cell death. The interest in these proteins ... -
Neutralizing properties of Varespladib toward group I and II myotoxic phospholipases A2
(2019)A need exists to develop specific and clinically useful inhibitors of toxic enzymes present in snake venoms, responsible for severe tissue damage and life-threatening effects occurring in thousands of people suffering ... -
Fomento de la promoción de la salud en adolescentes: desarrollo de una estrategia con estudiantes de sexto grado de la Escuela Juan Rafael Mora Porras durante el II semestre del 2016
(2020)Introducción:Este trabajo pretendió el desarrollo de una estrategia en promoción de la salud con adolescentes de la Escuela Juan Rafael Mora Porras, en la cual convergieron elementos en salud pública, la enfermería y la ... -
Relación entre indicadores antropométricos y masa grasa medida por deuterio en escolares costarricenses
(2019)El propósito de este estudio fue identificar la relación entre la masa grasa expresada como porcentaje de grasa corporal (%GC) medida por el método de deuterio (D2O) e indicadores antropométricos en escolares costarricenses. Se ... -
Distribución de subtipos de rhinovirus en niños atendidos en los meses de abril, mayo, junio, setiembre y octubre del 2014 en el Hospital Nacional de Niños y su asociación con el desarrollo de patologías respiratorias
(2020)Las infecciones del tracto respiratorio constituyen el principal motivo de consulta a los servicios de emergencias en todo el mundo, generando gastos millonarios en atención médica, así como en la pérdida de días laborales ...
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