• Pharmaceutical assistance programs to support smoking cessation medication access 

  León Salas, Angie; Hunt, Jamie J.; Richter, Kimber P.; Nazir, Niaman; Ellerbeck, Edward F.; Shireman, Theresa I. (2017-11-03)

  OBJECTIVES: Rural smokers are more likely to be uninsured and live in poverty, which may pose significant cost barriers to accessing smoking cessation medications. As part of a randomized clinical trial, we provided support ...

• Valor diagnóstico de las proteínas uPAR en sangre para el cáncer gástrico en Guatemala 

  Wellmann, Irmgardt A.; Villagrán, Carmen I.; Fernández Botrán, Rafael; Hernández, Elisa; Méndez Chacón, Ericka; Une, Clas Allan (2018)

  El cáncer gástrico es la neoplasia más frecuente del tubo digestivo, Guatemala posee altas tasas de incidencia y mortalidad. Helicobacter pylori se ha identificado como un carcinógeno gástrico, especialmente si la infección ...

• Design Challenges for Reconnecting in Later Life: A Qualitative Study 

  Ibarra, Francisco; Kowalik, Grzegorz; Baez, Marcos; Nielek, Radosław; Lau Sánchez, Norma; Cernuzzi, Luca; Casati, Fabio (2018-05-31)

  Friendships and social interactions are renown contributors to wellbeing. As such, keeping a healthy amount of relationships becomes very important as people age and the size of their social network tends to decrease. ...

• Evaluación del estado nutricional por medio de indicadores antropométricos en preescolares costarricenses 

  Zamora Salas, Juan Diego; Laclé Murray, Adriana (2018-12-14)

  El objetivo del estudio fue evaluar el estado nutricional de preescolares costarricenses. Se evaluaron 200 preescolares (100 niños y 100 niñas), edades comprendidas entre los 5 a 6 años de edad (5,6 ± 0,29 años). La ...

• Inequality in the Incidence of Cervical Cancer: Costa Rica 1980–2010 

  Santamaría Ulloa, Carolina; Valverde Manzanares, Cindy (2019-01-10)

  Introduction: Cervical cancer is the third most incident and the fourth most lethal cancer among Costa Rican women. The purpose of this study was to quantify incidence inequality along three decades and to explore its ...

• The effects of environmental enrichment and social isolation and their reversion on anxiety and fear conditioning 

  Mora Gallegos, Andrea; Fornaguera Trías, Jaime (2019-01)

  Animal models of fear and anxiety provide important insight into anxiety-related symptoms in humans. Environmental physical conditions and social contact influence behavior and brain plasticity particularly at early ...

• Virulence factor genotyping of Helicobacter pylori isolated from Costa Rican dyspeptic patients 

  Molina Castro, Silvia Elena; Garita Cambronero, Jerson; Malespín Bendaña, Wendy Karina; Une, Clas Allan; Ramírez Mayorga, Vanessa (2019-01-14)

  Background and aims: Costa Rica is one of the countries with the highest incidence and mortality rates for gastric cancer. Helicobacter pylori infection rates are high in the whole country. We have previously shown that ...

• La fragilidad de la memoria: creencias falsas y memoria autobiográfica, una revisión preliminar 

  Nájera Fernández, Joselyne; Salazar Villanea, Mónica; Fornaguera Trías, Jaime (2018)

  La memoria es un proceso reconstructivo, donde distintos recuerdos buscan conformar una narrativa autobiográfica coherente. No obstante, dichos recuerdos no son completamente precisos, ya que en diversas investigaciones ...

• Testing experience and environmental enrichment potentiated open-field habituation and grooming behaviour in rats 

  Rojas Carvajal, Mijail; Fornaguera Trías, Jaime; Mora Gallegos, Andrea; Brenes Sáenz, Juan Carlos (2018-03-13)

  In laboratory rats, one of the most used paradigms to assess habituation to novelty is the open-field test. Environmental enrichment has proved to be a reliable way to enhance open-field test habituation. Experiment 1, ...

• Priming the seed: Helicobacter pylori alters epithelial cell invasiveness in early gastric carcinogenesis 

  Molina Castro, Silvia Elena; Ramírez Mayorga, Vanessa; Alpízar Alpízar, Warner (2018-09-15)

  Helicobacter pylori (H. pylori) infection is a well-established risk factor for the development of gastric cancer (GC), one of the most common and deadliest neoplasms worldwide. H. pylori infection induces chronic inflammation ...

• Características clínicas y genético-moleculares de la enfermedad de Huntington en pacientes costarricenses: experiencia de 14 años de diagnóstico molecular 

  Vásquez Cerdas, Melissa; Morales Montero, Fernando; Cuenca Berger, Patricia (2018-11-13)

  Introducción: La enfermedad de Huntington (HD) es un trastorno neurodegenerativo hereditario, caracterizado por signos y síntomas motores, cognitivos y neuropsiquiátricos, causado por una expansión del trinucleótido ...

• Biological and proteolytic variation in the venom of Crotalus scutulatus scutulatus from Mexico 

  Borja, Miguel; Neri Castro, Edgar; Castañeda Gaytán, Gamaliel; Strickland, Jason L.; Parkinson, Christopher L.; Castañeda Gaytán, Juan; Ponce López, Roberto; Lomonte, Bruno; Olvera Rodríguez, Alejandro; Alagón Cano, Alejandro; Pérez Morales, Rebeca (2018-01)

  Rattlesnake venoms may be classified according to the presence/absence and relative abundance of the neurotoxic phospholipases A2s (PLA2s), such as Mojave toxin, and snake venom metalloproteinases (SVMPs). In Mexico, ...

• Intravascular hemolysis induced by phospholipases A2 from the venom of the Eastern coral snake, Micrurus fulvius: functional profile of hemolytic and non-hemolytic isoforms 

  Fernández Montes de Oca, María Laura; Lomonte, Bruno; Yunes Quartino, Pablo J.; Arce Bejarano, Ruth; Fernández Ulate, Julián; Camacho, Luis F.; Gutiérrez, José María; Kuemmel, Daniel; Fidelio, Gerardo Daniel (2018-04)

  A unique feature of the venom of Micrurus fulvius (Eastern coral snake) is its ability to induce severe intravascular hemolysis in particular species, such as dogs or mice. This effect was previously shown to be induced ...

• Pros and cons of different therapeutic antibody formats for recombinant antivenom development 

  Laustsen, Andreas Hougaard; Gutiérrez, José María; Knudsen, Cecilie; Johansen, Kristoffer H.; Bermúdez Méndez, Erick; Cerni, Felipe A.; Jürgensen, Jonas A.; Ledsgaard, Line; Martos Esteban, Andrea; Øhlenschlæger, Mia; Pus, Urska; Andersen, Mikael Rørdam; Lomonte, Bruno; Engmark, Mikael Gerling; Pucca, Manuela Berto (2018-05)

  Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many advances in immunology, synthetic biology, and antibody research, different approaches and antibody formats are being ...

• Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus 

  Sánchez Brenes, Andrés; Herrera Vega, María; Villalta Arrieta, Mauren; Solano, Daniela; Segura Ruíz, Álvaro; Lomonte, Bruno; Gutiérrez, José María; León Montero, Guillermo; Vargas Arroyo, Mariángela (2018-06)

  The protein composition and toxinological profile of the venom of the African spitting elapid Hemachatus haemachatus (Ringhals) were characterized by bottom-up proteomics and functional in vitro and in vivo assays. Venom ...

• Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms 

  Gutiérrez, José María; Rucavado, Alexandra; Escalante Muñoz, Teresa; Herrera Arias, Cristina; Fernández Ulate, Julián; Lomonte, Bruno; Fox, Jay W. (2018-06)

  Snakebite envenoming by viperid species, and by some elapids, is characterized by a complex pattern of tissue damage at the anatomical site of venom injection. In severe cases, tissue destruction may be so extensive as ...

• A myotoxic Lys49 phospholipase A2-homologue is the major component of the venom of Bothrops cotiara from Misiones, Argentina 

  de Roodt, Adolfo Rafael; Fernández Ulate, Julián; Solano, Daniela; Lomonte, Bruno (2018-04-27)

  Bothrops cotiara is a pitviper found in Southeastern Brazil and, scarcely, in the Misiones province of Argentina. In contrast to considerable information available on the venom of the Brazilian snake population, that of ...

• MipLAAO, a new L-amino acid oxidase from the redtail coral snake, Micrurus mipartitus 

  Rey Suárez, Paola; Acosta, Cristian; Torres Lamus, Uday Daniel; Saldarriaga Córdoba, Mónica Marı́a; Lomonte, Bruno; Núñez Rangel, Vitelbina (2018-06-08)

  L-amino acid oxidases (LAAOs) are ubiquitous enzymes in nature. Bioactivities described for these enzymes include apoptosis induction, edema formation, induction or inhibition of platelet aggregation, as well as antiviral, ...

• A snake venom secreted phospholipase A2 induces foam cell formation depending on the activation of factors involved in lipid homeostasis 

  Leiguez, Elbio; do Nascimento Viana, Mariana; Hideki Matsubara, Márcio; Fernandes, Cristina Maria; Giannotti, Karina Cristina; Gutiérrez, José María; Lomonte, Bruno; Teixeira, Catarina de Fátima (2018-06)

  MT-III, a snake venom GIIA sPLA2, which shares structural and functional features with mammalian GIIA sPLA2s, activates macrophage defense functions including lipid droplet (LDs) formation, organelle involved in both lipid ...

• Health-Related Quality of Life of Older Adults in Costa Rica as Measured by the Short-Form-36 Health Survey 

  Valdivieso Mora, Esmeralda; Ivanisevic, Mirjana; Shaw, Leslie A.; Garnier Villarreal, Mauricio; Green, Zachary D.; Salazar Villanea, Mónica; Moncada Jiménez, José; Johnson, David K. (2018-07)

  Objective: To test the validity of a common measure of health-related quality of life (Short-Form-36 [SF-36]) in cognitively healthy older adults living in rural and urban Costa Rica. Method: Confirmatory factor analysis ...

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