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Ultrastructural alterations in mouse capillary blood vessels after experimental injection of venom from the snake Bothrops asper (Terciopelo)
(1992-10)Histological and ultrastructural alterations in capillary blood vessels were studied at various time intervals after im injection of 50 micrograms of Bothrops asper snake venom in mouse gastrocnemius muscle. Hemorrhage was ... -
Umbilical Cord Immunoglobulins and Fetal Maturity: Neonates in a Guatemalan Indian Village
(1977)During a 9-year prospectivestudy in a Mayan Indian village (1), umbilical cord blood was collected by untrained midwivesfrom most newborns. Specimens mixed with maternal blood were screened according to their ratios ... -
Understanding and confronting snakebite envenoming: The harvest of cooperation
(2016-01)During 45 years, the Instituto Clodomiro Picado (ICP, University of Costa Rica) has developed an ambitious scientific, technological, productive, and social program aimed at providing a better understanding of snakes and ... -
Understanding of informed consent by patients at the Faculty of Dentistry of the University of Costa Rica
(2022-03)Introduction: Informed consent is the result of the evolution of the relationship between health professionals and their patients or users where the principle of autonomy is above anything else. There are many articles on ... -
Understanding structural and functional aspects of PII snake venom metalloproteinases: Characterization of BlatH1, a hemorrhagic dimeric enzyme from the venom of Bothriechis lateralis
(2014-06)A new homodimeric PII metalloproteinase, named BlatH1, was purified from the venom of the Central American arboreal viperid snake Bothriechis lateralis by a combination of anion-exchange chromatography, hydrophobic interaction ... -
Unexpected Functional Divergence of Bat Influenza Virus NS1 Proteins
(2018-02-12)Recently, two influenza A virus (FLUAV) genomes were identified in Central and South American bats. These sequences exhibit notable divergence from classical FLUAV counterparts, and functionally, bat FLUAV glycoproteins ... -
Unity makes strength: exploring intra and interspecies toxin synergism between phospholipases A2 and cytotoxins
(2020)Toxin synergism is a complex biochemical phenomenon, where different animal venom proteins interact either directly or indirectly to potentiate toxicity to a level that is above the sum of the toxicities of the individual ... -
Unravelling a vicious circle: animal feed marketed in Costa Rica contains irregular concentrations of tetracyclines and abundant oxytetracycline-resistant Gram-positive bacteria
(2014-04)Diverse tetracyclines are used to prevent and control bacterial infections in livestock and farmed fish. These drugs are administered through the diet, but farmers seldom check whether feed contains antibiotic-resistant ... -
Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms
(2018-06)Snakebite envenoming by viperid species, and by some elapids, is characterized by a complex pattern of tissue damage at the anatomical site of venom injection. In severe cases, tissue destruction may be so extensive as ... -
Unveiling the nature of black mamba (Dendroaspis polylepis) venom through venomics and antivenom immunoprofiling: identification of key toxin targets for antivenom development.
(2015-04-24)The venom proteome of the black mamba, Dendroaspis polylepis, from Eastern Africa, was, for the first time, characterized. Forty- different proteins and one nucleoside were identified or assigned to protein families. The ... -
Urban structure and dengue incidence in Puntarenas, Costa Rica
(2009-07-15)Dengue is currently the most important arboviral disease globally and is usually associated with built environments in tropical areas. Remotely sensed information can facilitate the study of urban mosquito-borne diseases ... -
Urokinase plasminogen activator receptor is expressed in invasive cells in gastric carcinomas from high- and low-risk countries
(International Journal of Cancer 146 año 2009 p. 405–415, 2009-07-16)Gastric cancer is the second cancer causing death worldwide. Both incidence and mortality rates vary according to geographical regions. The receptor for urokinase plasminogen activator (uPAR) is involved in extracellular ... -
Use of contraception and knowledge of health technologies
(1997)Are the behavioral aspects of use of family planning and primary health care services linked? The question addresses a key assumption in the rationale of reproductive health programs. In this paper we address the basic ... -
Uses and misuses of definitions of genetic polymorphism: A perspective from population pharmacogenetics
(1991)Definitions of genetic polymorphism currently employed in the pharmacological literature have been incorrectly used (Kalow, 1984) and uncritically imported from population genetics [e.g., Weinshilboum (1984), Evans (1977)], ... -
Using Geographical Information Systems to Identify Populations in Need of Improved Accessibility to Antivenom Treatment for Snakebite Envenoming in Costa Rica
(2013-01-31)INTRODUCTION: Snakebite accidents are an important health problem in rural areas of tropical countries worldwide, including Costa Rica, where most bites are caused by the pit-viper Bothrops asper. The treatment of these ... -
Using the Protein Leverage Hypothesis to understand socioeconomic variation in obesity
(2017-01-25)The protein leverage hypothesis (PLH) predicts that protein appetite will stimulate excess energy intake, and consequently obesity, when the proportion of protein in the diet is low. Experimental studies support the PLH, ... -
Uso correcto de la mascarilla
(2020) -
Uso de albúmina sérica humana en choque hemorrágico en el paciente adulto
(2023-10-15)La importancia de este estudio es determinar si existe evidencia que respalde el uso de la albúmina sérica humana como parte del manejo en el paciente en estado de choque hemorrágico, teniendo en cuenta su alto costo ... -
El uso de animales de experimentación en la investigación biomédica en Costa Rica
(Acta Médica Costarricense 52(3), 2010-07)El progreso en la investigación médica y biológica ha dependido en gran medida del uso de animales experimentales Dada la importancia que históricamente han tenido los animales como reactivos biológicos en la investigación ...