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El uso de animales de experimentación en la investigación biomédica en Costa Rica
Using Experimental Animal in Biomedical Research in Costa Rica
(Acta Médica Costarricense 52(3), 2010-07)
El progreso en la investigación médica y biológica ha dependido en gran medida del uso de animales experimentales Dada la importancia que históricamente han tenido los animales como reactivos biológicos en la investigación ...
Fragilidad osmótica de los eritrocitos de carnero en relación con su uso en el laboratorio clínico
(Revista Costarricense de Ciencias Médicas 14(1,2). 1993, 1993-03)
Al notar que los eritrocitos de carnero del Bioterio del Hospital San Juan de Dios, San José, Costa Rica, hemolizaban espontáneamente, fueron comparados, por medio de una serie de ensayos de fragilidad osmótica, con los ...
Immunohistochemical demonstration of the binding of bothrops asper myotoxin to skeletal muscle sarcolemma
The binding of Bothrops asper myotoxin to mouse skeletal muscle was studied at both the light and electron microscope levels using the peroxidase anti-peroxidase technique. The toxin binds to muscle cell sarcolemma, and ...
The need for an integrated approach in confronting snakebite envenoming in Latin America: the relevance of endogenous scientific and technological research
Hacia un abordaje integral del envenenamiento ofídico en América Latina: la importancia de la generación de conocimiento científico-tecnológico endógeno
Snakebite envenomings constitute a serious public health problem on a global level, especially in Africa, Asia and Latin America. In our Latin American region, it is estimated that at least 70,000 snakebite cases occur ...
Umbilical Cord Immunoglobulins and Fetal Maturity: Neonates in a Guatemalan Indian Village
During a 9-year prospectivestudy in a Mayan Indian village (1), umbilical cord blood was collected by untrained midwivesfrom most newborns. Specimens mixed with maternal blood were screened according to their ratios ...
Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities
Clostridium difficile strains within the hypervirulent clade 2 are responsible for nosocomial outbreaks worldwide. The increased pathogenic potential of these strains has been attributed to several factors but is still ...
Neutralization of myotoxic phospholipases A2 from the venom of the snake Bothrops asper by monoclonal antibodies
The neutralization of two myotoxic phospholipases A2 from the venom of Bothrops asper, myotoxins I and II, by two murine monoclonal antibodies is reported. The monoclonal antibodies, MAb-3 and Mab-4, recognize different ...
Molecular detection of Clostridium difficile on inert surfaces from a Costa Rican hospital during and after an outbreak
Background: Hospital transmission of Clostridium difficile is fostered by contamination of surfaces and medical equipment with spores highly resistant to disinfectants and regular cleaning procedures. Despite the outbreaks ...
A review of Bioinformatics training applied to research in Molecular Medicine, Agriculture and Biodiversity in Costa Rica and Central America
(Briefings in Bioinformatics, 14(5): 661-670, 2013-04-13)
Today, Bioinformatics has become a scientific discipline with great relevance for the Molecular Biosciences and for the Omics sciences in general. Although developed countries have progressed with large strides in ...
DNase activity in Costa Rican crotaline snake venoms: quantification of activity and identification of electrophoretic variants.
DNase activity of Costa Rican crotaline snake venoms from the genera Bothrops, Crotalus and Lachesis was quantified by an enzymodiffusion method on agarose/DNA gels containing ethidium bromide. The reaction is detected as ...