Now showing items 1071-1079 of 1079
Subconvulsant doses of pentylenetetrazol uncover the epileptic phenotype of cultured synapsin-deficient Helix serotonergic neurons in the absence of excitatory and inhibitory inputs
Synapsins are a family of presynaptic proteins related to several processes of synaptic functioning. A variety of reports have linked mutations in synapsin genes with the development of epilepsy. Among the proposed ...
Evaluación de contaminantes microbianos en muestras de cannabis incautadas en Costa Rica
Evaluation of microbial contamination in samples of cannabis seized in Costa Rica
Diferentes literaturas sugieren que el consumo de cannabis es un importante problema para la salud pública. El cannabis, por su naturaleza ilegal, llega a sus usuarios sin cumplimiento de normas adecuadas de cultivo, ...
Methylmercury increases S100B content in rat cerebrospinal fluid
S100B, a calcium binding protein physiologically produced and released by astrocytes, has been used as a peripheral marker of brain damage. Here, we investigated the effects of subcutaneous injections of methylmercury ...
Inhibition of the myotoxic activity of Bothrops aspermyotoxin II in mice by immunization with its synthetic 13-mer peptide 115-129
The region comprising amino acid residues 115±129 of myotoxin II, a Lys49 phospholipase A2 from the venom of Bothrops asper, was previously shown to constitute a heparin binding site, and to be associated with its toxic ...
Emergence of an Outbreak-Associated Clostridium difficile Variant with Increased Virulence
The prevalence of Clostridium difficile infections has increased due to the emergence of epidemic variants from diverse genetic lineages. Here we describe the emergence of a novel variant during an outbreak in a Costa Rican ...
Two Groups of Cocirculating, Epidemic Clostridiodes difficile Strains Microdiversify through Different Mechanisms
Clostridiodes difficile strains from the NAPCR1/ST54 and NAP1/ST01 types have caused outbreaks despite of their notable differences in genome diversity. By comparing whole genome sequences of 32 NAPCR1/ST54 isolates and ...
Recent treatment advances in HER2-positive metastatic breast cancer: a clinical approach
The use of targeted therapy directed against HER2 is currently the standard of care in patients with metastatic HER2-positive breast cancer. The combination of trastuzumab with a taxane as first-line treatment in HER2-positive ...
Ejercicio físico como tratamiento en el manejo de lumbalgia
Exercise as a treatment for low back pain management
La lumbalgia es un padecimiento que conlleva grandes repercusiones económicas, sociales y se ha convertido en una de las primeras causas de incapacidad laboral a nivel global. Cuando ocurre el dolor en la parte baja de la ...
Snake venomics of Bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: different evolutionary solutions for the same trophic purpose
We report the proteomic characterization and biological activities of the venom of the black-speckled palm pitviper, Bothriechis nigroviridis, a neotropical arboreal pitviper from Costa Rica. In marked contrast to other ...