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Proteomic and functional profiling of the venom of Bothrops ayerbei from Cauca, Colombia, reveals striking interspecific variation with Bothrops asper venom
(Journal of Proteomics Volume 96, 16 January 2014, Pages 159–172, 2014-01)
Bothrops ayerbei, a pitviper inhabiting the Patía River's basin (Valle Alto del Río Patía) in the Southwestern Department of Cauca, Colombia, was considered as a variant form of Bothrops asper prior to being proposed as a ...
Depletion of complement enhances the clearance of Brucella abortus in mice
(2018)
Brucellosis is a bacterial disease of animals and humans. Brucella abortus
barely activates the innate immune system at the onset of infection, and this
bacterium is resistant to the microbicidal action of complement. ...
Structure of myotoxin-II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom
(2006)
Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic
proteins which, although lacking catalytic activity, possess the ability to disrupt
biological membranes, inducing significant muscle-tissue loss ...
Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae)
(2011-01-31)
The proteome of the venom of Micrurus nigrocinctus (Central American coral snake) was analyzed by a “venomics” approach. Nearly 50 venom peaks were resolved by RP-HPLC, revealing a complex protein composition. Comparative ...
Bactericidal activity of Lys49 and Asp49 myotoxic phospholipases A2 from Bothrops asper snake venom: synthetic Lys49 myotoxin II-(115-129)-peptide identifies its bactericidal region
(1998)
Mammalian group-II phospholipases A2 (PLA2) of inflammatory fluids display bactericidal properties,
which are dependent on their enzymatic activity. This study shows that myotoxins II (Lys49) and III
(Asp49), two group-II ...
Determinación inmunoenzimática de los niveles séricos de inmunoglobina E en niños asmáticos de la Meseta Central de Costa Rica
(1991)
Se describe los niveles de IgE sérica en una muestra de 69 niños con diagnóstico de asma bronquial, de la meseta central de Costa Rica, así como de 33 niños aparentemente sanos, sin historia clínica de alergias, y de 20 ...
Neutralizing properties of Varespladib toward group I and II myotoxic phospholipases A2
(2019)
A need exists to develop specific and clinically useful inhibitors of toxic enzymes present in snake venoms,
responsible for severe tissue damage and life-threatening effects occurring in thousands of people suffering
...
Venomics of the poorly studied hognosed pitvipers Porthidium arcosae and Porthidium volcanicum
(2021)
We report the first proteomics analyses of the venoms of two poorly studied snakes, the Manabi hognosed pitviper Porthidium arcosae endemic to the western coastal province of Manabí (Ecuador), and the Costa Rican hognosed ...
Local effects induced by coral snake venoms: Evidence of myonecrosis after experimental inoculations of venoms from five species
(1983)
The local effects induced by intramuscular inoculations of venons from six species of coral snakes were studied in mice. Venoms of Micrurus nlgrocinctus nigrocinctus, M. n . moquitensis, M. alleni, M. frontalis, M. aarinkauda ...
Proteomic and toxicological analysis of the venom of Micrurus yatesi and its neutralization by an antivenom
(2022)
Coralsnakes belong to the family Elapidae and possess venoms which are lethal to humans and can be grouped based on the predominance of either three finger toxins (3FTxs) or phospholipases A2 (PLA2s). A proteomic and ...