Buscar
Mostrando ítems 281-290 de 358
Amino acid sequence and biological characterization of BlatPLA2, a non-toxic acidic phospholipase A2 from the venom of the arboreal snake Bothriechis lateralis from Costa Rica
(2013-10)
Bothriechis is considered a monophyletic, basal genus of arboreal Neotropical pitvipers
distributed across Middle America. The four species found in Costa Rica (B. lateralis, B.
schlegeli, B. nigroviridis, B. supraciliaris) ...
Intravascular hemolysis induced by phospholipases A2 from the venom of the Eastern coral snake, Micrurus fulvius: functional profile of hemolytic and non-hemolytic isoforms
(2018-04)
A unique feature of the venom of Micrurus fulvius (Eastern coral snake) is its ability to induce severe intravascular
hemolysis in particular species, such as dogs or mice. This effect was previously shown to be induced ...
Venomics of Leiurus abdullahbayrami, the most lethal scorpion in the Levant region of the Middle East
(2024)
The scorpion Leiurus abdullahbayrami has been associated with severe/lethal envenomings throughout the Levant region of the Middle East, encompassing Turkey, Syria, and Lebanon, and only scarce information is available on ...
Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920)
(2019)
The World Health Organization recently listed snakebite envenoming as a Neglected Tropical Disease,
proposing strategies to significantly reduce the global burden of this complex pathology by 2030. In
this context, ...
La actividad proteolítica de los venenos de serpientes de Costa Rica sobre la caseína
(Revista de Biologia Tropical 31(1), 37-40, 1983)
Se establecen las condiciones óptimas para la determinación comparativa de la actividad proteolítica de los venenos de serpientes costarricenses sobre la caseína y se describe dicha actividad para 13 venenos diferentes. ...
Proteomic and functional analysis of the venom of Porthidium lansbergii lansbergii (Lansberg’s hognose viper) from the Atlantic Department of Colombia
(2015)
The venom of the Lansberg's hognose pitviper, Porthidium lansbergii lansbergii, a species found in the northern region of Colombia, is poorly known. Aiming to increase knowledge on Porthidium species venoms, its proteomic ...
The synthetic Varespladib molecule is a multi-functional inhibitor for PLA2 and PLA2-like ophidic toxins
(2021)
The treatment for snakebites is early administration of antivenom, which can be highly effective in inhibiting the systemic effects of snake venoms, but is less effective in the treatment of extra-circulatory and local ...
Phospholipase A2 and inflammation
Pathobiological activities of human group II phospholipase A2 in inflammation: do they all depend on its enzymatic action?
(1995)
Increased expression of secreted group II phospholipase A 2 (sPLA2) is associated with inflammation 1.This enzyme can promote a variety of potentially harmful events, which have been attributed to its catalytic activity. ...
In vivo neutralization of the dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG monoclonal antibodies
(2018)
The black mamba (Dendroaspis polylepis) is one of the most feared snake species of the
African savanna. It has a potent, fast-acting neurotoxic venom comprised of dendrotoxins and
α-neurotoxins associated with high ...
Biochemical characterization and pharmacological properties of a phospholipase A2 myotoxin inhibitor from the plasma of the snake Bothrops asper
(1997-09-15)
A protein that neutralizes the biological activities of basic phospholipase A2 (PLA2) myotoxin isoforms from the venom of the snake Bothrops asper was isolated from its blood by affinity chromatography with Sepharose-immobilized ...