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Toxicity of Bothrops sp snake venoms from Ecuador and preclinical assessment of the neutralizing efficacy of a polyspecific antivenom from Costa Rica 

Laines, Johana; Segura Ruiz, Álvaro; Villalta Arrieta, Mauren; Herrera Vega, María; Vargas Arroyo, Mariángela; Alvarez, Gladys; Gutiérrez, José María; León Montero, Guillermo (2014-09-15)
The toxicological profile of the venoms of the snakes Bothrops asper and Bothrops atrox from Ecuador was investigated, together with the venom of a population of B. asper formerly classified as ‘Bothrops xanthogrammus’. ...

Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP) for the treatment of viper envenoming in sub-Saharan Africa 

Segura Ruiz, Álvaro; Villalta Arrieta, Mauren; Herrera Vega, María; León Montero, Guillermo; Harrison, Robert A.; Durfa, Nandul; Nasidi, Abdulsalami; Calvete Chornet, Juan José; Theakston, R. David G.; Warrell, David A.; Gutiérrez, José María (2010-02)
A preclinical assessment was performed on the neutralizing efficacy of a whole IgG polyspecific antivenom (EchiTAb-Plus-ICP®), designed for the treatment of snakebite envenomings in Nigeria. It was generated by immunizing ...

Study of the design and analytical properties of the lethality neutralization assay used to estimate antivenom potency against Bothrops asper snake venom 

Solano Trejos, María Gabriela; Segura Ruiz, Álvaro; Herrera Vega, María; Gómez Argüello, Aarón; Villalta Arrieta, Mauren; Gutiérrez, José María; León Montero, Guillermo (2010-09)
The lethality neutralization assay performed in mice is the standard recommended by the World Health Organization to estimate antivenom potency. The interpretation of its results without considering its analytical capacity ...
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Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows 

Estrada Umaña, Ricardo; Herrera Vega, María; Segura Ruiz, Álvaro; Araya, Javier; Boschini Figueroa, Carlos; Gutiérrez, José María; León Montero, Guillermo (2010-11)
Administration of antivenoms to treat snakebite envenomings has the potential risk of inducing early adverse reactions. The mechanisms involved in these reactions are unclear. In this study, polyspecific antivenom consisting ...
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Trends in Snakebite Envenomation Therapy: Scientific, Technological and Public Health Considerations 

Gutiérrez, José María; Lomonte, Bruno; León Montero, Guillermo; Rucavado Romero, Alexandra; Chaves Mora, Fernando; Angulo Ugalde, Yamileth (2007)
The therapy of snakebite envenomation has been based on the parenteral administration of animal-derived antivenoms. Despite the success of this treatment at reducing the impact of snakebite mortality and morbidity, mostly ...
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Antivenoms for the treatment of snakebite envenomings: The road ahead 

Gutiérrez, José María; León Montero, Guillermo; Burnouf, Thierry (2011-05)
The parenteral administration of antivenoms is the cornerstone of snakebite envenoming therapy. Efforts are made to ensure that antivenoms of adequate efficacy and safety are available world-wide. We address the main issues ...

Anti-human erythrocyte antibodies in horse-derived antivenoms used in the treatment of snakebite envenomations 

León Montero, Guillermo; Rodríguez, Miguel Angel; Rucavado Romero, Alexandra; Lomonte, Bruno; Gutiérrez, José María (2007-03)
This work examined the presence of antibodies reacting with human erythrocytes in horse-derived antivenoms used in the treatment of snakebite envenomations, and assessed the efficacy of various fractionation protocols in ...

Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms 

León Montero, Guillermo; Herrera Vega, María; Segura Ruiz, Álvaro; Villalta Arrieta, Mauren; Vargas Arroyo, Mariángela; Gutiérrez, José María (2013-12-15)
Snake antivenoms are formulations of immunoglobulins, or immunoglobulin fragments, purified from the plasma of animals immunized with snake venoms. Their therapeutic success lies in their ability to mitigate the progress ...
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Factors associated with adverse reactions induced by caprylic acid-fractionated whole IgG preparations: comparison between horse, sheep and camel IgGs 

Herrera Vega, María; León Montero, Guillermo; Segura Ruiz, Álvaro; Meneses, Fabricio; Lomonte, Bruno; Chippaux, Jean Philippe; Gutiérrez, José María (2005-12)
Caprylic acid purification of IgG, currently used in the manufacture of horse-derived antivenoms, was successfully adapted for the preparation of sheep and camel IgG. Sheep IgG had a molecular mass of approximately 150 ...
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La situación de los antivenenos liofilizados en América Latina: Aspectos tecnológicos y de salud pública
Freeze-dried antivenoms in latin america: technological and public health considerations 

Gutiérrez, José María; Herrera Vega, María; León Montero, Guillermo (2012)
La administración parenteral de antivenenos constituye el elemento central en la terapia de los envenenamientos por mordeduras o picaduras de animales ponzoñosos. En América Latina existen laboratorios productores de ...
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León Montero, Guillermo (57)
Gutiérrez, José María (52)Herrera Vega, María (33)Segura Ruiz, Álvaro (31)Villalta Arrieta, Mauren (26)Vargas Arroyo, Mariángela (20)Lomonte, Bruno (17)Estrada Umaña, Ricardo (10)Angulo Ugalde, Yamileth (9)Calvete Chornet, Juan José (9)... View MoreType
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  • Repositorios universitarios

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  • @Ciencia_UCR
  • Sobre Kérwá
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Contact Us | Send Feedback
Repositorio Institucional de la Universidad de Costa Rica. Algunos derechos reservados. Este repositorio funciona con DSpace.
Universidad de Costa Rica