Now showing items 31-40 of 2180
Anemia de células falciformes
(Gaceta Médica de Costa Rica, vol. 8, n. 1, enero-junio, 2006, 2006)
La enfermedad de células falciformes es un término usado para describir un grupo de desórdenes autosómicos recesivos, caracterizados por producción de hemoglobina anormal.
Validación de la técnica QF-PCR para el diagnóstico de cromosomopatías en Costa Rica
Introducción. Las cromosomopatías autosómicas más frecuentes son las trisomías de los cromosomas 21, 18 y 13. En Costa Rica, el diagnóstico de anomalías cromosómicas fetales y neonatales se realiza solo mediante el ...
Pathogenesis of dermonecrosis induced by venom of the spitting cobra, Naja nigricollis: An experimental study in mice
The pathogenesis of dermonecrosis induced by the venom of the African spitting cobra Naja nigricollis was investigated in a mouse model. Intradermal injection of venom induced a macroscopic necrotic lesion. Histological ...
Biological and biochemical activities of Vipera berus (European viper) venom
Vipera berus is widely distributed throughout the northern part of Europe and Asia. Characterization of several toxic effects of its venom in the mouse, as well as of in vitro enzymatic activities was performed. Vipera ...
Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows
Administration of antivenoms to treat snakebite envenomings has the potential risk of inducing early adverse reactions. The mechanisms involved in these reactions are unclear. In this study, polyspecific antivenom consisting ...
Toxicity of Bothrops sp snake venoms from Ecuador and preclinical assessment of the neutralizing efficacy of a polyspecific antivenom from Costa Rica
The toxicological profile of the venoms of the snakes Bothrops asper and Bothrops atrox from Ecuador was investigated, together with the venom of a population of B. asper formerly classified as ‘Bothrops xanthogrammus’. ...
Freeze-dried snake antivenoms formulated with sorbitol, sucrose or mannitol: Comparison of their stability in an accelerated test
Freeze-drying is used to improve the long term stability of pharmaceutical proteins. Sugars and polyols have been successfully used in the stabilization of proteins. However, their use in the development of freeze-dried ...
Antivenomics of Atropoides mexicanus and Atropoides picadoi snake venoms: Relationship to the neutralization of toxic and enzymatic activities
Viperid snakes of the genus Atropoides are distributed in Mexico and Central America and, owing to their size and venom yield, are capable of provoking severe envenomings in humans. This study evaluated, using an ‘antivenomics’ ...
Oral rehydration and maintenance of children with rotavirus and bacterial diarrhoeas
Rehydratation mr vole orale et maintien de l'equilibre chez les jeunes enfants atteints de diarrhee a rotavirus ou a bacteries
(Bull World Health Organ. 1979; 57(3): 453–459, 1979)
To determine whether oral glucose-electrolytes therapy could be adapted with equal success to infants with diarrhoea of bacterial and viral etiologies, oral glucose-electrolytes therapy was studied in a setting where all ...
Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms
Species of the genus Bothrops induce the vast majority of snakebite envenomings in Latin America. A preclinical study was performed in the context of a regional network of public laboratories involved in the production, ...