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Autocatalytic acylation of phospholipase-like myotoxins 

Pedersen, J. Z.; Lomonte, Bruno; Massoud, R.; Gubensek, F.; Gutiérrez, José María; Rufini, Stefano (1995-04)
Several snake venoms contain a phospholipase A2 in which position 49 in the active site is occupied by a lysine or a serine instead of the aspartate residue normally found. Although these proteins do not bind Ca2+ and are ...

Functional analysis of DM64, an antimyotoxic protein with immunoglobulin-like structure from Didelphis marsupialis serum 

Rocha, Surza Lucia Gonçalves; Lomonte, Bruno; Neves Ferreira, Ana Gisele da Costa; Trugilho, Monique Ramos de Oliveira; Junqueira de Azevedo, Inácio de Loiola Meirelles; Ho, Paulo Lee; Domont, Gilberto B.; Gutiérrez, José María; Perales, Jonas (2002-12-11)
Bothrops snake venoms are known to induce local tissue damage such as hemorrhage and myonecrosis. The opossum Didelphis marsupialis is resistant to these snake venoms and has natural venom inhibitors in its plasma. The aim ...
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El suero de neonatos de Clelia clelia (Serpentes: Colubridae) neutraliza la acción hemorrágica del veneno de Bothrops asper (Serpentes: Viperidae). 

Lomonte, Bruno; Cerdas Fallas, Luis; Solórzano López, Alejandro; Martínez, Soledad (1989)
The ability of serum from nine newbom specimens of Clelia clelia (Colubridae) to neutralize hernorrhagic action of Bothrops asper venom was tested. All serum samples neutralized completely the hernorrhagic effect of the ...
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Utilidad de los péptidos sintéticos en estudios de estructura-función e identificación de epitopos en toxinas 

Lomonte, Bruno (Bruno Lomonte. (2014). Utilidad de los péptidos sintéticos en estudios de estructura-función e identificación de epitopos en toxinas. Cuba: RED BIOTOX-CYTED. pp.71-80, 2014)
Los péptidos sintéticos han ganado un lugar relevante dentro de la “caja de herramientas” de la investigación biomédica actual. Las técnicas de síntesis automatizada y el costo decreciente de los procesos, unidas a mejoras ...

Myotoxic phospholipases A2 in Bothrops snake venoms: Effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu 

Andrião Escarso, Silvia H.; Soares, Andreimar Martins; Rodrigues, Veridiana M.; Angulo Ugalde, Yamileth; Díaz Oreiro, Cecilia; Lomonte, Bruno; Gutiérrez, José María; Giglio, José Roberto (2000-08)
Venoms from eight Bothrops spp. were fractionated by ion-exchange chromatography on CM-Sepharose at pH 8.0 for the purification of myotoxins. Chromatographic profiles showed differences regarding myotoxic components among ...

Isolation and characterization of four medium-size disintegrins from the venoms of Central American viperid snakes of the genera Atropoides, Bothrops, Cerrophidion and Crotalus 

Angulo Ugalde, Yamileth; Castro Godínez, Adriana; Lomonte, Bruno; Rucavado Romero, Alexandra; Fernández Ulate, Julián; Calvete Chornet, Juan José; Gutiérrez, José María (2014-12)
Four disintegrins were isolated from the venoms of the Central American viperid snakes Atropoides mexicanus (atropoimin), Bothrops asper (bothrasperin), Cerrophidion sasai (sasaimin), and Crotalus simus (simusmin). ...

Evaluación de la capacidad de cuatro antivenenos comerciales para neutralizar el veneno de la serpiente Bothrops asper (terciopelo) de Costa Rica 

Bogarín, Guisella; Segura, Eduardo; Durán, Gina; Lomonte, Bruno; Rojas Céspedes, Gustavo; Gutiérrez, José María (1995-09)
We studied the ability of four commercially available antivenoms to neutralize several toxic and enzymatic activities of Bothrops asper (terciopelo) venom from Costa Rica. Experiments with preincubation of venom and antivenom ...

Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene 

Alape Girón, Alberto; Flores Díaz, Marietta; Guillouard, Isabelle; Naylor, Claire E.; Titball, Richard; Rucavado Romero, Alexandra; Lomonte, Bruno; Basak, Ajit K.; Gutiérrez, José María; Cole, Steward T.; Thelestam, Mónica (2000-08)
Clostridium perfringens phospholipase C (PLC), also called α-toxin, is the major virulence factor in the pathogenesis of gas gangrene. The toxic activities of genetically engineered α-toxin variants harboring single ...

Isolation and characterization of basic myotoxic phospholipases A2 from Bothrops godmani (Godman's pit viper) snake venom 

Díaz Oreiro, Cecilia; Gutiérrez, José María; Lomonte, Bruno (1992)
Two basic myotoxic phospholipases A2 were purified to homogeneity from the venom of Bothrops godmani from Costa Rica by ion-exchange chromatography on CM-Sephadex. They have molecular weights of 14,300 (myotoxin I) and ...
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Phospholipases a2 from Viperidae snakes: Differences in membranotropic activity between enzymatically active toxin and its inactive isoforms 

Ghazaryan, Narine A.; Ghulikyan, Lusine; Kishmiryan, Arsen; Andreeva, Tatyana V.; Utkin, Yuri N.; Tsetlin, Victor I.; Lomonte, Bruno; Ayvazyan, Naira M. (Biochimica et Biophysica Acta - Biomembranes vol 1848: 463–468, 2015-02)
We describe the interaction of various phospholipases A2 (PLA2) from snake venoms of the family Viperidae (Macrovipera lebetina obtusa, Vipera ursinii renardi, Bothrops asper) with giant unilamellar vesicles (GUVs) composed ...
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Lomonte, Bruno (297)
Gutiérrez, José María (177)Angulo Ugalde, Yamileth (59)Calvete Chornet, Juan José (43)Sanz, Libia (34)Fernández Ulate, Julián (33)Rucavado Romero, Alexandra (22)León Montero, Guillermo (17)Rojas Céspedes, Gustavo (15)Sasa Marín, Mahmood (15)... View MoreTypeinfo:eu-repo/semantics/article (283)Artículo científico (254)info:eu-repo/semantics/bookPart (8)Capítulo de libro (7)Contribución a publicación periódica (3)info:eu-repo/semantics/contributionToPeriodical (3)info:eu-repo/semantics/doctoralThesis (1)info:eu-repo/semantics/other (1)info:eu-repo/semantics/preprint (1)Preprint (1)... View MoreProcedenceVicerrectoría de Investigación (297)Vicerrectoría de Docencia (48)... View MoreHas File(s)Yes (297)

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