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Inhibitory effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phospholipases A2 from Bothrops snake venoms: isolation of 4-nerolidylcatechol as active principle
(2005)
Phospholipases A2 (PLA2) are important constituents of snake venoms, being responsible for several of their toxic actions.
Extracts from plants used in folk medicine were screened for inhibition of the enzymatic activity ...
Venomics of the Duvernoy's gland secretion of the false coral snake Rhinobothryum bovallii (Andersson, 1916) and assessment of venom lethality towards synapsid and diapsid animal models
(2020)
The Duvernoy's gland secretory proteome of the false coral snake Rhinobothryum bovallii (Costa Rica), unveiled applying bottom-up venomics, comprises a handful of toxins belonging to only three protein families, three-finger ...
Anticomplementary activity of equine whole IgG antivenoms: comparison of three fractionation protocols
(2005-01)
Early adverse reactions occur in a number of patients treated with heterologous antivenoms and have been associated with anticomplementary activity (ACA). In order to reduce the ACA of equine whole IgG antivenoms produced ...
Pathogenesis of myonecrosis induced by coral snake (Micrurus nigrocinctus) venom in mice
(1986-02)
The mode by which coral snake (Micrurus nigrocinctus) venom affects skeletal muscle was studied using a combined approach. The venom induced early functional and structural alterations in the plasma membrane of muscle ...
Development of nanobodies against hemorrhagic and myotoxic components of Bothrops atrox snake venom
(2020)
Snake envenoming is a globally neglected public health problem. Antivenoms produced using animal hyperimmune plasma remain the standard therapy for snakebites. Although effective against systemic effects, conventional ...
Strategies in 'snake venomics' aiming at an integrative view of compositional, functional, and immunological characteristics of venoms
(2017-04)
This work offers a general overview on the evolving strategies for the proteomic analysis of snake venoms, and
discusses how these may be combined through diverse experimental approaches with the goal of achieving a
more ...
Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A2 from the Central American coral snake, Micrurus nigrocinctus
(2017)
Snakebite envenomings represent a neglected public health issue in many parts of the
rural tropical world. Animal-derived antivenoms have existed for more than a hundred
years and are effective in neutralizing snake venom ...
N-terminal peptide of myotoxin II from Bothrops asper venom enhances the activity of endothelin converting enzyme and neprilysin
(2016)
Neprilysin (NEP) and endothelin converting enzyme-1 (ECE-1) are two enzymes that degrade amyloid
beta in the brain. Currently there are no molecules to stimulate the activity of these enzymes. Here
we report, the discovery ...
From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy
(2016)
The snake is the symbol of medicine due to its association with Asclepius, the
Greek God of medicine, and so with good reasons. More than 725 species of venomous
snakes have toxins specifically evolved to exert potent ...
Exploring the venom of the forest cobra snake: Toxicovenomics and antivenom profiling of Naja melanoleuca
(2017-01-06)
A toxicovenomic analysis of the venomof the forest cobra, N. melanoleuca,was performed, revealing the presence
of a total of 52 proteins by proteomics analysis. The most abundant proteins belong to the three-finger ...