Low endemicity and low pathogenicity of rotaviruses among rural children in Costa Rica
artículo original
Fecha
1985Autor
Simhon Edgar, Alberto
Mata Jiménez, Leonardo
Vives Blanco, Marcela
Rivera, L.
Vargas, S.
Ramírez, Giselle
Lizano, Lucía
Catarinella Arrea, Gabriela
Azofeifa Navas, Jorge
Metadatos
Mostrar el registro completo del ítemResumen
Rotaviruses were prospectively studied in 51 rural Costa Rican children from birth to two
years. Samples of feces were collected weekly over a 33-month period. Rotavirus was detected
in 45 (1.04%) of 4,317 fecal specimens; 39 infections were documented (an incidence
of 0.5 infection per child-year), only five of which were associated with diarrhea
(a pathogenicity of 12.8%). Secretory antibody in fecal extracts, detected in six of 39 infections,
was short lived and did not protect against reinfection. Serum antibody was present
in 69.6% of two-year-old children, but was not detected in 18.8% with documented infections.
On the other hand, serum antibody was present in six of 14 children in whom rotavirus
was not detected, thus increasing the overall incidence to 0.6 infection per child-year. The
combination of prolonged breast-feeding, exposure to a lower infecting dose (compared
with urban children), and a higher standard of hygiene than expected may explain the
low incidence and low pathogenicity of rotavirus among these rural children.
Artículo científico -- Universidad de Costa Rica. Instituto de Investigaciones en Salud. 1985