Listar Microbiología por autor "Rangel Hasbún, José Andrés"
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Membrane cholesterol modulates the cytolytic mechanism of myotoxin II, a Lys49 phospholipase A2 homologue from the venom of Bothrops asper
Rangel Hasbún, José Andrés; Quesada, Orestes; Gutiérrez, José María; Angulo Ugalde, Yamileth; Lomonte, Bruno (2011-04-19)Lys49 phospholipase A2 (PLA2) homologues present in crotalid snake venoms lack enzymatic activity, yet they induce skeletal muscle necrosis by a membrane permeabilizing mechanism whose details are only partially understood. ... -
Snake venom Lys49 myotoxins: from phospholipases A2 to non-enzymatic membrane disruptors
Lomonte, Bruno; Rangel Hasbún, José Andrés (2012-09)Snake venoms often contain toxins that cause a rapid necrosis of skeletal muscle fibers, referred to as myotoxins. The most common among them are phospholipases A2 (PLA2s), enzymes that have two independent evolutionary ...