Listar Microbiología por autor "Spolaore, Barbara"

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    • Cell surface nucleolin interacts with and internalizes Bothrops asper Lys49 phospholipase A2 and mediates its toxic activity 

      Lina Massimino, Maria; Simonato, Morena; Spolaore, Barbara; Franchin, Cinzia; Arrigoni, Giorgio; Marin, Oriano; Monturiol Gross, Laura; Fernández Ulate, Julián; Lomonte, Bruno; Tonello, Fiorella (2018)
      Phospholipases A2 are a major component of snake venoms. Some of them cause severe muscle necrosis through an unknown mechanism. Phospholipid hydrolysis is a possible explanation of their toxic action, but catalytic and ...

    • Enzymatic labelling of venom phospholipase A2 toxins 

      Spolaore, Barbara; Fernández Ulate, Julián; Lomonte, Bruno; Massimino, Maria Lina; Tonello, Fiorella (2019)
      Almost all animal venoms contain secretory phospholipases A2 (PLA2s), 14 kDa disulfide-rich enzymes that hydrolyze membrane phospholipids at the sn-2 position, releasing lysophospholipids and fatty acids. These proteins, ...