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Antivenomic Characterization of Two Antivenoms Against the Venom of the Taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia 

Herrera Vega, María; Paiva, Owen K.; Pagotto, Ana Helena; Segura Ruiz, Álvaro; Serrano, Solange M. T.; Vargas Arroyo, Mariángela; Villalta Arrieta, Mauren; Jensen, Simon D.; León Montero, Guillermo; Williams, David J.; Gutiérrez, José María (2014-11-05)
Antivenoms manufactured by bioCSL Limited (Australia) and Instituto Clodomiro Picado (Costa Rica) against the venom of the taipan snakes (Oxyuranus scutellatus) from Australia and Papua New Guinea (PNG), respectively, were ...

Freeze-dried snake antivenoms formulated with sorbitol, sucrose or mannitol: Comparison of their stability in an accelerated test 

Herrera Vega, María; Tattini Jr., Virgilio; Pitombo, Ronaldo N. M.; Gutiérrez, José María; Borgognoni, Camila; Vega Baudrit, José Roberto; Solera, Federico; Cerdas Solís, Maykel; Segura Ruiz, Álvaro; Villalta Arrieta, Mauren; Vargas Arroyo, Mariángela; León Montero, Guillermo (2014-11)
Freeze-drying is used to improve the long term stability of pharmaceutical proteins. Sugars and polyols have been successfully used in the stabilization of proteins. However, their use in the development of freeze-dried ...

Pathogenesis of dermonecrosis induced by venom of the spitting cobra, Naja nigricollis: An experimental study in mice 

Rivel Piedra, Mario; Solano, Daniela; Herrera Vega, María; Vargas Arroyo, Mariángela; Villalta Arrieta, Mauren; Segura Ruiz, Álvaro (2016-09-01)
The pathogenesis of dermonecrosis induced by the venom of the African spitting cobra Naja nigricollis was investigated in a mouse model. Intradermal injection of venom induced a macroscopic necrotic lesion. Histological ...
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Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows 

Estrada Umaña, Ricardo; Herrera Vega, María; Segura Ruiz, Álvaro; Araya, Javier; Boschini Figueroa, Carlos; Gutiérrez, José María; León Montero, Guillermo (2010-11)
Administration of antivenoms to treat snakebite envenomings has the potential risk of inducing early adverse reactions. The mechanisms involved in these reactions are unclear. In this study, polyspecific antivenom consisting ...

Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms 

Segura Ruiz, Álvaro; Castillo, M. C.; Núñez Rangel, Vitelbina; Yarlequé, A.; Gonçalves, Luís Roberto de Camargo; Villalta Arrieta, Mauren; Bonilla, César; Herrera Vega, María; Fernández, M.; Yano, M. Y.; Araújo, H. P.; Boller, M. A. A.; León, P.; Tintaya, B.; Sano Martins, I. S.; Gómez, A.; Fernández, Gil Patrick; Geoghegan, Patricia; Higashi, Hisako Gondo; León Montero, Guillermo; Gutiérrez, José María (2010-11)
Species of the genus Bothrops induce the vast majority of snakebite envenomings in Latin America. A preclinical study was performed in the context of a regional network of public laboratories involved in the production, ...

Study of the design and analytical properties of the lethality neutralization assay used to estimate antivenom potency against Bothrops asper snake venom 

Solano Trejos, María Gabriela; Segura Ruiz, Álvaro; Herrera Vega, María; Gómez Argüello, Aarón; Villalta Arrieta, Mauren; Gutiérrez, José María; León Montero, Guillermo (2010-09)
The lethality neutralization assay performed in mice is the standard recommended by the World Health Organization to estimate antivenom potency. The interpretation of its results without considering its analytical capacity ...

Lachesis stenophrys venom reduces the equine antibody response towards Bothrops asper venom used as co-immunogen in the production of polyspecific snake antivenom 

Arroyo Portilla, Cynthia; Solano Rojas, Sergio; Herrera Vega, María; Segura Ruiz, Álvaro; Estrada Umaña, Ricardo; Vargas Arroyo, Mariángela; Villalta Arrieta, Mauren; León Montero, Guillermo (2015-09-01)
The anti-bothropic activity of an antivenom prepared from the plasma of horses immunized with Bothrops asper venom (anti-B antivenom) was compared with a similar formulation produced from the plasma of horses immunized ...

Evaluation of the preclinical efficacy of four antivenoms, distributed in sub-Saharan Africa, to neutralize the venom of the carpet viper, Echis ocellatus, from Mali, Cameroon, and Nigeria 

Sánchez Céspedes, Laura Vanessa; Pla Ferrer, Davinia; Herrera Vega, María; Chippaux, Jean Philippe; Calvete Chornet, Juan José; Gutiérrez, José María (2015-11)
Snakebite envenoming causes a heavy toll in sub-Saharan Africa in terms of mortality and sequelae. In the West African savannah, the viperid Echis ocellatus is responsible for the vast majority of bites. In the last decades, ...

Neutralization of the neuromuscular inhibition of venom and taipoxin from the taipan (Oxyuranus scutellatus) by F(ab0)2 and whole IgG antivenoms 

Herrera Vega, María; de Cássia de O. Collaço, Rita; Villalta Arrieta, Mauren; Segura Ruiz, Álvaro; Vargas Arroyo, Mariángela; Wright, Christine E.; Paiva, Owen K.; Matainaho, Teatulohi; Jensen, Simon D.; León Montero, Guillermo; Williams, David J.; Rodrigues Simioni, Lea; Gutiérrez, José María (2016-01-22)
The neuromuscular junction activity of Oxyuranus scutellatus venom and its presynaptic neurotoxin, taipoxin, and their neutralization by two antivenoms were examined in mouse phrenic nerve-diaphragm preparations. The action ...

Purification of equine whole IgG snake antivenom by using an aqueous two phase system as a primary purification step 

Vargas Arroyo, Mariángela; Segura Ruiz, Álvaro; Villalta Arrieta, Mauren; Herrera Vega, María; Gutiérrez, José María; León Montero, Guillermo (2015-01)
There is a need to introduce innovations in the manufacture of snake antivenoms to increase the supply of these products worldwide. In this work, the fractionation of equine hyperimmune plasma with a new methodology that ...
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Herrera Vega, María (39)
Gutiérrez, José María (36)León Montero, Guillermo (35)Segura Ruiz, Álvaro (33)Villalta Arrieta, Mauren (29)Vargas Arroyo, Mariángela (24)Estrada Umaña, Ricardo (10)Calvete Chornet, Juan José (9)Lomonte, Bruno (6)Sanz, Libia (6)... View MoreTypeinfo:eu-repo/semantics/article (37)artículo científico (35)info:eu-repo/semantics/bookPart (1)info:eu-repo/semantics/patent (1)ProcedenceVicerrectoría de Investigación (39)Vicerrectoría de Docencia (2)... View MoreHas File(s)Yes (37)No (2)

  • Repositorios universitarios

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