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Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation, molecular cloning and biological properties
(2000-03-15)
Myotoxic phospholipases A2 (PLA2s; group II) account for most of the muscle-tissue damage that results from envenomation by viperid snakes. In the venom of the Godman's viper (Cerrophidion godmani, formerly Bothrops godmani), ...
A randomized blinded clinical trial of two antivenoms, prepared by caprylic acid or ammonium sulphate fractionation of IgG, in Bothrops and Porthidium snake bites in Colombia: correlation between safety and biochemical characteristics of antivenoms
(1999-06)
A randomized blinded clinical trial was performed in 53 patients bitten by Bothrops sp. and Porthidium sp. in Antioquia and Chocó, Colombia, in order to compare the efficacy and safety of two antivenoms made of whole IgG ...
Efecto del suero antiofídico sobre la actividad hemolítica del complemento humano (in vitro) y de conejo (in vitro e in vivo).
(1989)
En el presente trabajo se investigó el efecto del suero antiofídico polivalente, producido en Costa Rica, sobre la actividad hemolítica (CH50) del complemento sérico humano (in vitro) y de conejo (in vitro e in vivo). ...
A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo)
(1989)
A new muscle damaging toxin, myotoxin II, was purified from the venom of Bothrops asper by ion-exchange chromatography on CMSephadex C-25. The toxin is a dimeric, basic protein with a monomer mol.wt of 13,341, according ...
Purification and characterization of BaH4, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper
(2000-01)
A hemorrhagic metalloproteinase, named BaH4, was isolated from the venom of the snake Bothrops asper by a combination of ion-exchange chromatography on DEAE-Sepharose and gel filtration on Sephacryl S-200. BaH4 is a 69 kDa ...
Exposure of dogs to spotted fever group rickettsiae in urban sites associated with human rickettsioses in Costa Rica
(2016-07)
The zoonotic transmission cycles of Rickettsia rickettsii and other spotted fever group (SFG) rickettsiae
in Latin America have usually been associated with rural or sylvatic environments, although domestic
dogs can be ...
El suero antiofídico polivalente producido en Costa Rica: Estabilidad y capacidad neutralizante
(1988)
En este trabajo se revisan y discuten una serie
de aspectos relativos a la producción,
estabilidad y capacidad neutralizante del suero
antiofídico polivalente producido por el Instituto
Clodomiro Picado. Este suero ...
A biocomputational platform for the automated construction of large-scale mathematical models of miRNA-transcription factor networks for studies on gene dosage compensation
(2016-11-09)
Cancer complexity and resistance is mediated by
cell-to-cell heterogeneity, which is the consequence of the
enormous instability of its genetic material. It is unknown how
cancer cells are able to withstand the effects ...
Molecular Characterization of Two Major Dengue Outbreaks in Costa Rica
(2016-07)
Dengue virus (DENV) (Flavivirus, Flaviviridae) is a reemerging arthropod-borne virus with a worldwide
circulation, transmitted mainly by Aedes aegypti and Aedes albopictus mosquitoes. Since the first detection of its ...
El virus del Zika
Zika virus
(2016-01)
El virus del Zika es un arbovirus emergente. Se transmite
por medio de los mosquitos del género Aedes. Fue descrito
por primera vez en mosquitos y monos del bosque Zika en
Uganda, en 1947; posteriormente, en seres humanos ...