Buscar
Mostrando ítems 11-20 de 35
Snake Venomics of African Spitting Cobras: Toxin Composition and Assessment of Congeneric Cross-Reactivity of the Pan-African EchiTAb-Plus-ICP Antivenom by Antivenomics and Neutralization Approaches
(2011)
Venomic analysis of the venoms of Naja nigricollis, N. katiensis, N. nubiae, N. mossambica, and N. pallida revealed similar compositional trends. The high content of cytotoxins and PLA2s may account for the extensive tissue ...
Purification of equine whole IgG snake antivenom by using an aqueous two phase system as a primary purification step
(2015-01)
There is a need to introduce innovations in the manufacture of snake antivenoms to increase the supply of these products worldwide. In this work, the fractionation of equine hyperimmune plasma with a new methodology that ...
Assessing the preclinical efficacy of antivenoms: From the lethality neutralization assay to antivenomics
(2013-07)
The assessment of the capacity of antivenoms to neutralize the lethal activity of snake
venoms is the gold standard in the preclinical analysis of antivenom efficacy, and is
routinely performed by manufacturers and quality ...
Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows
(2010-11)
Administration of antivenoms to treat snakebite envenomings has the potential risk of inducing early adverse reactions. The mechanisms involved in these reactions are unclear. In this study, polyspecific antivenom consisting ...
Comparison of the effect of Crotalus simus and Crotalus durissus ruruima venoms on the equine antibody response towards Bothrops asper venom: Implications for the production of polyspecific snake antivenoms
(2011-02)
Antivenoms are preparations of immunoglobulins purified from the plasma of animals immunized with snake venoms. Depending on the number of venoms used during the immunization, antivenoms can be monospecific (if venom from ...
Freeze-dried snake antivenoms formulated with sorbitol, sucrose or mannitol: Comparison of their stability in an accelerated test
(2014-11)
Freeze-drying is used to improve the long term stability of pharmaceutical proteins. Sugars and polyols have been successfully used in the stabilization of proteins. However, their use in the development of freeze-dried ...
Development of a chicken-derived antivenom against the taipan snake (Oxyuranus scutellatus) venom and comparison with an equine antivenom
(2016-09-15)
A chicken-derived antivenom (ChDAv) towards taipan snake (Oxyuranus scutellatus) venom was produced
by purifying anti-taipan IgY from egg yolks of hens immunized with taipan venom. The productivity,
antivenomic profile, ...
Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP) for the treatment of viper envenoming in sub-Saharan Africa
(2010-02)
A preclinical assessment was performed on the neutralizing efficacy of a whole IgG polyspecific antivenom (EchiTAb-Plus-ICP®), designed for the treatment of snakebite envenomings in Nigeria. It was generated by immunizing ...
Human heterophilic antibodies against equine immunoglobulins: assessment of their role in the early adverse reactions to antivenom administration
(2008)
The presence of human heterophilic antibodies against horse immunoglobulins
(HHA-HI) was determined by ELISA in sera from healthy volunteers and from patients who
received equine antivenom for therapy of snake bite ...
Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus
(2018-06)
The protein composition and toxinological profile of the venom of the African spitting elapid Hemachatus haemachatus
(Ringhals) were characterized by bottom-up proteomics and functional in vitro and in vivo assays.
Venom ...