Now showing items 11-20 of 381
Neutralization of myotoxic phospholipases A2 from the venom of the snake Bothrops asper by monoclonal antibodies
The neutralization of two myotoxic phospholipases A2 from the venom of Bothrops asper, myotoxins I and II, by two murine monoclonal antibodies is reported. The monoclonal antibodies, MAb-3 and Mab-4, recognize different ...
Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms
Species of the genus Bothrops induce the vast majority of snakebite envenomings in Latin America. A preclinical study was performed in the context of a regional network of public laboratories involved in the production, ...
The C-terminal region of a Lys49 myotoxin mediates Ca2þ influx in C2C12 myotubes
Myotoxins are abundant components of snake venoms, being a significant public health problem worldwide. Among them, Lys49 phospholipase A2 homologue myotoxins cause extensive necrosis in skeletal muscle tissue. Their ...
Backbone Flexibility Controls the Activity and Specificity of a Protein−Protein Interface: Specificity in Snake Venom Metalloproteases
Protein-protein interfaces have crucial functions in many biological processes. The large interaction areas of such interfaces show complex interaction motifs. Even more challenging is the understanding of (multi)specificity ...
Isolation and characterization of synergistic hemorrhagins from the venom of the snake Bothrops asper
Three hemorrhagic factors (BaH1, BH2 and BH3) were isolated from the venom of Bothrops asper by gel filtration on Sephacryl S-200, DEAE-Sepharose chromatography, metal chelate affinity chromatography and hydrophobic ...
Desarrollo de las universidades públicas de Latinoamérica: una visión alternativa al modelo economicista de rentabilidad
Development of public universities in latin america: an alternative perspective to the economicist model of profitability
Los modelos ideológico-económicos preponderantes en Latinoamérica en las últimas décadas han impuesto un concepto estrecho de rentabilidad económica en muchas áreas de la sociedad, incluyendo aquellas en las que se ...
Development of a chicken-derived antivenom against the taipan snake (Oxyuranus scutellatus) venom and comparison with an equine antivenom
A chicken-derived antivenom (ChDAv) towards taipan snake (Oxyuranus scutellatus) venom was produced by purifying anti-taipan IgY from egg yolks of hens immunized with taipan venom. The productivity, antivenomic profile, ...
The need for an integrated approach in confronting snakebite envenoming in Latin America: the relevance of endogenous scientific and technological research
Hacia un abordaje integral del envenenamiento ofídico en América Latina: la importancia de la generación de conocimiento científico-tecnológico endógeno
Snakebite envenomings constitute a serious public health problem on a global level, especially in Africa, Asia and Latin America. In our Latin American region, it is estimated that at least 70,000 snakebite cases occur ...
Pathogenesis of myonecrosis induced by coral snake (Micrurus nigrocinctus) venom in mice
The mode by which coral snake (Micrurus nigrocinctus) venom affects skeletal muscle was studied using a combined approach. The venom induced early functional and structural alterations in the plasma membrane of muscle ...