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Estudio de la capacidad ofiófaga y la resistencia de la zopilota (Clelia clelia, Colubridae) de Costa Rica a los venenos de serpiente
(1982)
The resistance of the non-venomous snake Clelia clelia (Colubridae) to 13 venoms of both viperid and elapid snakes was tested. Specimens were subjected to natural bites by venomous snakes and were injected with measured ...
Varespladib (LY315920) and methyl Varespladib (LY333013) abrogate or delay lethality induced by presynaptically-acting neurotoxic snake venoms
(2020)
The phospholipase A2 (PLA2) inhibitor Varespladib (LY315920) and its orally bioavailable prodrug, methyl-Varespladib (LY333013) inhibit PLA2 activity of a wide variety of snake venoms. In this study, the ability of these ...
An Asp49 Phospholipase A2 from Snake Venom Induces Cyclooxygenase-2 Expression and Prostaglandin E2 Production via Activation of NF-κB, p38MAPK, and PKC in Macrophages
(2014)
Phospholipases A2 (PLA2) are key enzymes for production of lipid mediators. We previously demonstrated that a snake venom sPLA2 named MT-III leads to prostaglandin (PG)E2 biosynthesis in macrophages by inducing the expression ...
Serum antibody response to polysaccharides in children with recurrent respiratory tract infections
(2001)
We evaluated children (15-months old and older) with recurrent upper respiratory tract infections and normal
levels of immunoglobulins in serum for specific polysaccharide immunodeficiency using an enzyme-linked
immunosorbent ...
Immunochemical properties of the N-terminal helix of myotoxin II, a lysine-49 phospholipase A2 from Bothrops asper snake venom
(2001)
Myotoxic class II phospholipases A2 from snake venoms can be divided into Asp49 and Lys49 types. The latter, including
Bothrops asper myotoxin II, exert membrane damage despite lacking catalytic activity. A heparin-binding, ...
Toxinological profile and histopathological alterations induced by Bothrocophias campbelli venom from Colombia
(2024)
Snakebite envenomings most frequently reported in Colombia are caused by snakes of the genera Bothrops, Bothriechis, Bothrocophias, and Porthidium. Their venoms induce local and systemic pathophysiological effects, sometimes ...
Nociones de Inmunologia
(2018)
La primera versión de este breve texto nació en 1990, con el objetivo de presentar al estudiante una visión rápida de los principios generales de la Inmunología, a un nivel introductorio. El texto está dirigido principalmente ...
Innovative immunization strategies for antivenom development
(2018)
Snakes, scorpions, and spiders are venomous animals that pose a threat to human
health, and severe envenomings from the bites or stings of these animals must be treated with
antivenom. Current antivenoms are based on ...
Envenomations by Bothrops and Crotalus Snakes Induce the Release of Mitochondrial Alarmins
(PLoS Negl Trop Dis 6(2): e1526, 2012-02-21)
Skeletal muscle necrosis is a common manifestation of viperid snakebite envenomations. Venoms from snakes of the genus Bothrops, such as that of B. asper, induce muscle tissue damage at the site of venom injection, provoking ...
Isolation of a galactose-binding lectin from the venom of the snake Bothrops godmani (Godmann's pit viper).
(1990)
A galactose-binding
lectin, isolated from the venom of B. gotlmani by affinity chromatography . is
an acidic protein (pI 4.9) with a subunit mol. wt of about 14,000, occurring
mostly as a disulfide-linked dimer of 28,000. ...