Now showing items 221-230 of 249
The dynamics of local tissue damage induced by Bothrops asper snake venom and myotoxin II on the mouse cremaster muscle: an intravital and electron microscopic study
The acute tissue damaging effects of Bothrops riper snake venom and a myotoxic Lys-49 phospholipase A2 (myotoxin In on the mouse cremaster muscle were studied by intravital and electron microscopy. Both venom and myotoxin ...
Neutralization of the cytolytic and myotoxic activities of phospholipases A2 from Bothrops asper snake venom by glycosaminoglycans of the heparin/heparan sulfate family
Basic phospholipases A2 from the venom of Bothrops asper exhibit skeletal muscle damaging activity in vivo, and cytolytic activity to a variety of cell types in culture. Glycosaminoglycans of the heparin/heparan sulfate ...
Inhibition of the myotoxic activity of Bothrops aspermyotoxin II in mice by immunization with its synthetic 13-mer peptide 115-129
The region comprising amino acid residues 115±129 of myotoxin II, a Lys49 phospholipase A2 from the venom of Bothrops asper, was previously shown to constitute a heparin binding site, and to be associated with its toxic ...
Bactericidal and anti-endotoxic properties of short cationic peptides derived from a snake venom Lys49 phospholipase A2
The activities of short synthetic, nonhemolytic peptides derived from the C-terminal region of myotoxin II, a catalytically inactive phospholipase A2 homologue present in the venom of the snake Bothrops asper, have been ...
Inhibitory effect of fucoidan on the activities of crotaline snake venom myotoxic phospholipases A2
Myotoxic phospholipases A2 account for most of the muscle necrosis that results from envenenomation by crotaline snakes. In this study, we investigated the protective effect of fucoidan, a natural sulfated polysaccharide ...
Venom, venomics, antivenomics
Venoms comprise mixtures of peptides and proteins tailored by Natural Selection to act on vital systems of the prey or victim. Here we review our proteomic protocols for uncoiling the composition, immunological profile, ...
Synthetic peptides derived from the C-terminal region of Lys49 phospholipase A2 homologues from Viperidae snake venoms: biomimetic activities and potential applications
Lys49-phospholipase A2 homologues constitute a large family of toxins present in the venoms of viperid snake species, which despite lacking catalytic activity, cause significant skeletal muscle necrosis. The main structural ...
Mortality by Hymenoptera stings in Costa Rica, 1985-2006
Mortalidad por picaduras de himenópteros en Costa Rica, 1985–2006
Objective. To analyze mortality due to Hymenoptera stings in Costa Rica during 1985–2006. Methods. Records of deaths due to Hymenoptera stings in 1985–2006 were retrieved from Instituto Nacional de Estadística y Censos ...
Susceptibilidad de Trypanosoma cruzi a diferentes venenos de serpientes de Costa Rica
Susceptibility of Trypanosoma cruzi to different Costa Rican snake venoms
Se evaluaron los efectos tóxicos de los venenos de cinco serpientes costarricenses en cuanto a su capacidad tripanocida contra dos cepas de Trypanosoma cruzi y sus efectos en cuanto a los mecanismos de muerte celular. ...
Ability of fucoidan to prevent muscle necrosis induced by snake venom myotoxins: comparison of high- and low-molecular weight fractions
Fucoidan, a natural polysaccharide extracted from brown seaweed, inhibits the myotoxic phospholipases A2 present in the venoms of crotalid snakes. This study evaluated the influence of molecular weight on the ability of ...