Now showing items 241-249 of 249
Tissue pathology induced by snake venoms: How to understand a complex pattern of alterations from a systems biology perspective?
The study of snake venom-induced local tissue pathology has been predominantly based on experimental designs and concepts that view tissue alterations from a dichotomous, homogeneous and reductionist perspective. Experimental ...
Snake venomics of the South and Central American Bushmasters. Comparison of the toxin composition of Lachesis muta gathered from proteomic versus transcriptomic analysis
We report the proteomic characterization of the venoms of two closely related pit vipers of the genus Lachesis, L. muta (South American Bushmaster) and L. stenophrys (Central American Bushmaster), and compare the toxin ...
Trends in Snakebite Envenomation Therapy: Scientific, Technological and Public Health Considerations
The therapy of snakebite envenomation has been based on the parenteral administration of animal-derived antivenoms. Despite the success of this treatment at reducing the impact of snakebite mortality and morbidity, mostly ...
Cytotoxicity induced in myotubes by a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops asper: Evidence of rapid plasma membrane damage and a dual role for extracellular calcium
Acute muscle tissue damage, myonecrosis, is a typical consequence of envenomations by snakes of the family Viperidae. Catalytically-inactive Lys49 phospholipase A2 homologues are abundant myotoxic components in viperid ...
Systemic and local myotoxicity induced by snake venom group II phospholipases A2: Comparison between crotoxin, crotoxin B and a Lys49 PLA2 homologue
The patterns of myotoxicity induced in mice by crotoxin, crotoxin B and a Lys49 phospholipase A2 (PLA2) homologue were compared. Lys49 PLA2-induced local myotoxicity is reflected by creatine kinase (CK) loss in injected ...
Intravascular hemolysis induced by the venom of the Eastern coral snake, Micrurus fulvius, in a mouse model: Identification of directly hemolytic phospholipases A2
(Toxicon 90, 2014)
Intravascular hemolysis has been described in envenomings by the Eastern coral snake, Micrurus fulvius, in dogs. An experimental model of intravascular hemolysis was developed in mice after intravenous (i.v.) injection ...
Dissociation of enzymatic and toxic activities by the use of antibodies
Disociación de las actividades enzimáticas y tóxicas mediante la utilización de anticuerpos
IN A RECENT article KASTURi and GOWDA,(1990) described the dissociation of enzymatic and toxic activities of phospholipases A, (PLA) from Vipera russelli venom by neutraliza- tion experiments u ...
Proteomic and toxicological profiling of the venom of Bothrocophias campbelli, a pitviper species from Ecuador and Colombia
(Toxicon 90, 2014)
Detailed snake venom proteomes for nearly a hundred species in different pitviper genera have accumulated using ‘venomics’ methodologies. However, venom composition for some lineages remains poorly known. Bothrocophias ...
Omics Meets Biology: Application to the Design and Preclinical Assessment of Antivenoms
(Toxins vol.6:3388-3405, 2014-12-15)
Snakebite envenoming represents a neglected tropical disease that has a heavy public health impact worldwide, mostly affecting poor people involved in agricultural activities in Africa, Asia, Latin America and Oceania. A ...