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Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA2 from Bothrops asper venom
(2004-12-01)
Suramin is a highly charged polysulfonated napthylurea that interferes in a number of physiologically relevant processes such as myotoxicity, blood coagulation and several kinds of cancers. This synthetic compound was ...
Phospholipases a2 from Viperidae snakes: Differences in membranotropic activity between enzymatically active toxin and its inactive isoforms
(Biochimica et Biophysica Acta - Biomembranes vol 1848: 463–468, 2015-02)
We describe the interaction of various phospholipases A2 (PLA2) from snake venoms of the family Viperidae
(Macrovipera lebetina obtusa, Vipera ursinii renardi, Bothrops asper) with giant unilamellar vesicles (GUVs)
composed ...
Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper
(2000-07-15)
Batimastat (BB-94), a synthetic hydroxamate peptidomimetic matrix metalloproteinase inhibitor, was tested for its ability to inhibit proteolytic and toxic effects induced by BaP1, a 24-kDa hemorrhagic metalloproteinase ...
Preclinical assessment of the ability of polyvalent (Crotalinae) and anticoral (Elapidae) antivenoms produced in Costa Rica to neutralize the venoms of North American snakes
(2003-06)
Polyvalent (Crotalinae) and anticoral (Elapidae) antivenoms produced by Instituto Clodomiro Picado, Costa Rica, were assessed for their ability to neutralize various toxic activities of the venoms of North American snakes ...
The Phospholipase A2 Homologues of Snake Venoms: Biological Activities and Their Possible Adaptive Roles
(2009)
A particular subgroup of toxins with phospholipase A2 (PLA2) structure, but devoid of this enzymatic activity, is commonly found in the venoms of snakes of the family Viperidae, and known as the PLA2 homologues. Among ...
Porphyromonas spp. have an extensive host range in ill and healthy individuals and an unexpected environmental distribution: a systematic review and meta-analysis
(2020-10-01)
Studies on the anaerobic bacteria Porphyromonas, mainly focused on P. gingivalis, have revealed new bacterial structures, metabolic pathways, and physiologic functionalities. Porphyromonas are mainly described as being ...
Bioavailability of in-feed tetracyclines is influenced to a greater extent by crude protein rather than calcium
(2014-12)
Feed is a common vehicle for tetracycline administration in animal farming. However, veterinarians and farmers often overlook that common feed components, such as proteins and calcium, may interact with these drugs and ...
Infectious agents in acute and chronic diarrhea of chilhood
(Chronic diarrea a in children: Raven Press p. 237 - 252, 1984)
Even today acute diarrheal disease is thought of by many laymen as well as by some medical professionals in developing countries as being a syndrome of alimentary origin. Despite recognition of shigellosis, cholera, ...
Blaesoxipha plinthopyga (Diptera: Sarcophagidae) como responsable de miasis nosocomiales en Costa Rica
Blaesoxipha plinthopyga (Diptera: Sarcophagidae) as an agent responsible for nosocomial myiasis in Costa Rica
(2014)
Se presentan dos casos de miasis nosocomiales, ocurridos en hospitales costarricenses, cuyo agente etiológico identificado fue Blaesoxipha plinthopyga (Diptera: Sarcophagidae). El primero tuvo lugar como infestación de una ...
Pathogenic potential of a Costa Rican strain of ‘Candidatus Rickettsia amblyommii’ in guinea pigs (Cavia porcellus) and protective immunity against Rickettsia rickettsii
(2015-07)
‘Candidatus Rickettsia amblyommii’ is a spotted fever group rickettsia that is not considered pathogenic, although there is serologic evidence of possible infection in animals and humans. The aim of this study was to ...