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Effects of chemical modifications of crotoxin B, the phospholipase A2 subunit of crotoxin from Crotalus durissus terrificus snake venom, on its enzymatic and pharmacological activities
(2001-09-01)
Crotoxin B, the basic Asp49-PLA2 subunit from crotoxin, the main component of Crotalus durissus terrificus venom, displays myotoxic, edema-inducing, bactericidal (upon Escherichia coli), liposomal-disrupting and anticoagulant ...
Ultrastructural alterations in mouse capillary blood vessels after experimental injection of venom from the snake Bothrops asper (Terciopelo)
(1992-10)
Histological and ultrastructural alterations in capillary blood vessels were studied at various time intervals after im injection of 50 micrograms of Bothrops asper snake venom in mouse gastrocnemius muscle. Hemorrhage was ...
Development of a chicken-derived antivenom against the taipan snake (Oxyuranus scutellatus) venom and comparison with an equine antivenom
(2016-09-15)
A chicken-derived antivenom (ChDAv) towards taipan snake (Oxyuranus scutellatus) venom was produced
by purifying anti-taipan IgY from egg yolks of hens immunized with taipan venom. The productivity,
antivenomic profile, ...
Characterization of a novel snake venom component: Kazal-type inhibitor-like protein from the arboreal pitviper Bothriechis schlegelii
(2016-06)
Snake venoms are composed mainly of a mixture of proteins and peptides. Notably, all snake venom toxins have been assigned to a small number of protein families. Proteomic studies on snake venoms have recently identified ...
A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo)
(1989)
A new muscle damaging toxin, myotoxin II, was purified from the venom of Bothrops asper by ion-exchange chromatography on CMSephadex C-25. The toxin is a dimeric, basic protein with a monomer mol.wt of 13,341, according ...
Human heterophilic antibodies against equine immunoglobulins: assessment of their role in the early adverse reactions to antivenom administration
(2008)
The presence of human heterophilic antibodies against horse immunoglobulins
(HHA-HI) was determined by ELISA in sera from healthy volunteers and from patients who
received equine antivenom for therapy of snake bite ...
Low pH formulation of whole IgG antivenom: Impact on quality, safety, neutralizing potency and viral inactivation
(2012-03)
Low pH treatment improves the tolerance to intravenous infusion, the stability, and the viral safety of various therapeutic immunoglobulins G preparations, but has never been evaluated for horse plasma-derived antivenoms. ...
Isolation and biochemical, functional and structural characterization of a novel L-amino acid oxidase from Lachesis muta snake venom
(2012-12-01)
The aim of this study was the isolation of the LAAO from Lachesis muta venom (LmLAAO) and its biochemical, functional and structural characterization. Two different purification protocols were developed and both provided ...
Envenamiento por mordedura de serpiente en Costa Rica en 1996: Epidemiología y consideraciones clínicas
(1999-12)
El presente trabajo se efectúa para tener una visión actualizada y completa de las principales características epidemiológicas del envenenamiento por mordedura de serpiente en Costa Rica. Asimismo, se incluyen algunas ...
Dr. Clodomiro Picado Twight (1887-1944)
(2010)
Semblanza de Clodomiro Picado Twight, quien jugó un papel central en el desarrollo inicial de varias ramas de la ciencia en Costa Rica. Su formación académica se inició en el Colegio San Luis Gonzaga, en Cartago, donde ...