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Isolation and characterization of four medium-size disintegrins from the venoms of Central American viperid snakes of the genera Atropoides, Bothrops, Cerrophidion and Crotalus
(2014-12)
Four disintegrins were isolated from the venoms of the Central American viperid snakes Atropoides mexicanus (atropoimin), Bothrops asper (bothrasperin), Cerrophidion sasai (sasaimin), and Crotalus simus (simusmin). ...
Novel catalytically-inactive PII metalloproteinases from a viperid snake venom with substitutions in the canonical zinc-binding motif
(2016-10-12)
Snake venom metalloproteinases (SVMPs) play key biological roles in prey immobilization
and digestion. The majority of these activities depend on the hydrolysis of relevant protein substrates
in the tissues. Hereby, we ...
Homogenates of skeletal muscle injected with snake venom inhibit myogenic differentiation in cell culture
(2013-02)
Introduction: Viperid snakebite envenomings are characterized by muscle necrosis and a deficient regenerative response. Methods: Homogenates from gastrocnemius muscles of mice injected with the venom of the snake Bothrops ...
Wound exudate as a proteomic window to reveal different mechanisms of tissue damage by snake venom toxins
(2009)
In light of the complexity of wound tissue, proteomic analysis may not clearly reveal the nature of the wound or the processes involved in healing. However, exudate associated with wounds may provide a “window” on cellular ...
Characterization of events associated with apoptosis/anoikis induced by snake venom metalloproteinase BaP1 on human endothelial cells
(2005-02)
Human endothelial EA.hy926 cells were incubated with BaP1, a hemorrhagic metalloproteinase purified from Bothrops asper snake venom. Since the first hour of incubation with the proteinase, cells started showing DNA ...
Neutralization of myonecrosis, hemorrhage, and edema induced by Bothrops asper snake venom by homologous and heterologous pre-existing antibodies in mice
(1996)
The ability of pre-existing antibodies to neutralize locally-acting toxins of Bothrops
asper snake venom was investigated. Hemorrhage, myonecrosis, and edema
were markedly reduced in actively immunized mice, although ...
Immunological studies on BaH1 and BaPI, two hemorrhagic metalloproteinases from the venom of the snake Bothrops asper
(1995-08)
No immunological cross-reactivity was observed between BaH1 and BaP1, two hemorrhagic metalloproteinases isolated from B. asper venom, by gel immunodiffusion, Western blotting and neutralization studies. Cross-reactivity ...
Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper
(1998-08)
Blister formation and skin damage can be induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper. Pathological changes in the skin were investigated after intramuscular injections of ...
Metaloproteinasas dependientes de Zinc: Protagonistas centrales en la Fisiopatología de Envenenamientos por Serpientes de la familia Viperidae
(2016)
Se presenta y discute el papel que juegan las metaloproteinasas de los venenos de serpientes (SVMPs) de la familia Viperidae en la fisiopatología de los envenenamientos inducidos por mordeduras de estos reptiles. Se hace ...
Effect of adjuvants on the antibody response of mice to Bothrops asper (Terciopelo) snake venom
(1996)
The adjuvant properties of several immunostimulant molecules on the murine antibody response to Bothrops asper snake venom were evaluated. Mice receiving venom together with either sodium alginate, calcium alginate, aluminum ...