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Critical role of TLR2 and MyD88 for functional response of macrophages to a group IIA-Secreted phospholipase A2 from snake venom 

Leiguez, Elbio; Giannotti, Karina Cristina; Moreira, Vanessa; Matsubara, Marcio Hideki; Gutiérrez, José María; Lomonte, Bruno; Rodríguez, Juan Pablo; Balsinde, Jesus; Teixeira, Catarina de Fátima (PLoS One 9(4):e93741, 2014-04-09)
The snake venom MT-III is a group IIA secreted phospholipase A2 (sPLA2) enzyme with functional and structural similarities with mammalian pro-inflammatory sPLA2s of the same group. Previously, we demonstrated that MT-III ...

Secretory phospholipases A2 isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases 

Moreira, Vanessa; Gutiérrez, José María; Soares, Andreimar Martins; Zamunér, Stella Regina; Purgatto, Eduardo; Teixeira, Catarina de Fátima (2008-09-01)
The effects of myotoxin III (MT-III), a phospholipase A2 (sPLA2) from Bothrops asper snake venom, and crotoxin B (CB), a neurotoxic and myotoxic sPLA2 from the venom of Crotalus durissus terrificus, on cyclooxygenases ...

Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro 

Moreira, Vanessa; Gutiérrez, José María; Amaral, Rafaela Bacci; Zamunér, Stella Regina; Teixeira, Catarina de Fátima; Amaral, Rafaela Bacci (2009-03)
In this study, the ability of Bothrops asper snake venom (BaV) to increase the production of prostaglandins PGE2 and PGD2 was assessed in a mouse model in vivo and in inflammatory cells in vitro. In addition, the expressions ...
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La investigación en la Universidad de Costa Rica: situación actual y perspectivas 

Gutiérrez, José María
En este trabajo se analizan algunas de las características actuales de la actividad de investigación científico-tecnológica en la Universidad de Costa Rica (UCR) y se plantean medidas tendientes a consolidar esta importante ...

Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom 

Rucavado Romero, Alexandra; Lomonte, Bruno; Ovadia, Michael; Gutiérrez, José María (1995-12)
The pathogenesis of hemorrhage and other local effects induced by the metalloproteinase BaP1, isolated from Bothrops asper venom, was investigated using various in vivo and in vitro models. Upon intramuscular injection in ...

Mortality due to snakebite envenomation in Costa Rica (1993–2006) 

Fernández, Pablo; Gutiérrez, José María (2008-09-01)
The mortality due to snakebite envenomation in Costa Rica for the period 1993–2006 was investigated by a retrospective analysis. There were 48 fatalities due to snakebites during this period. Mortality rates ranged from ...

The Global Snake Bite Initiative: an antidote for snake bite 

Williams, David J.; Gutiérrez, José María; Harrison, Robert A.; Warrell, David A.; White, Julian; Winkel, Kenneth D.; Gopalakrishnakone, Ponnampalam (2010-01-02)
Clinicians have for a long time witnessed the tragedy of injury, disability, and death from snake bite that is a daily occurrence in many parts of Africa, Asia, and Latin America. To many people living in these ...

An MTT-based method for the in vivo quantification of myotoxic activity of snake venoms and its neutralization by antibodies 

Lomonte, Bruno; Gutiérrez, José María; Romero, Marjorie; Núñez, Javier; Tarkowski, Andrej; Hanson, Lars Ake (1993-05)
The reduction of the tetrazolium compound MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) was used as the basis for the development of a simple method for the quantitative estimation of metabolically ...

Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage 

Rucavado Romero, Alexandra; Soto Morera, Mónica; Kamiguti, Aura S.; Theakston, R. David G.; Fox, Jay W.; Escalante Muñoz, Teresa; Gutiérrez, José María (2001-04)
Thrombocytopenia occurs in a number of patients bitten by Bothrops asper, a species responsible for the majority of snakebites in Central America and southern Mexico. In this work we describe the isolation of a new ...

Pathological alterations induced by neuwiedase, a metalloproteinase isolated from Bothrops neuwiedi snake venom 

Rodrigues, Veridiana M.; Soares, Andreimar Martins; Andrião Escarso, Silvia H.; Franceschi, Aida; Rucavado Romero, Alexandra; Gutiérrez, José María; Giglio, José Roberto (2001-06)
The pathological alterations induced by neuwiedase, a 22 kDa class P-I metalloproteinase from the venom of the South American pit viper Bothrops neuwiedi, were studied in mice. Neuwiedase was devoid of hemorrhagic activity ...
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Gutiérrez, José María (381)
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