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Assessing the preclinical efficacy of antivenoms: From the lethality neutralization assay to antivenomics
(2013-07)
The assessment of the capacity of antivenoms to neutralize the lethal activity of snake
venoms is the gold standard in the preclinical analysis of antivenom efficacy, and is
routinely performed by manufacturers and quality ...
Método para la producción de formulaciones inyectables de productos proteicos hemoderivados y productos obtenidos utilizando dicho método
(2011-04-08)
The invention relates to a method for producing injectable pharmaceutical formulations of blood-derived protein materials, including the steps of fractioning the source material in a polymer/salt aqueous two-phasesystem ...
Anti-human erythrocyte antibodies in horse-derived antivenoms used in the treatment of snakebite envenomations
(2007-03)
This work examined the presence of antibodies reacting with human erythrocytes in horse-derived antivenoms used in the treatment of snakebite envenomations, and assessed the efficacy of various fractionation protocols in ...
Caracterización de la toxicidad de venenos de serpiente sobre nauplios de Artemia salina y su utilidad para la evaluación de la potencia neutralizante de antivenenos ofídicos.
(2023-06-30)
Los antivenenos ofídicos son soluciones de inmunoglobulinas purificadas a partir del plasma de animales que han sido inmunizados con veneno de serpiente y administrados oportunamente, constituyen la única herramienta ...
Effect of Preservatives on IgG Aggregation, Complement-activating Effect and Hypotensive Activity of Horse Polyvalent Antivenom Used in Snakebite Envenomation
(2002-06)
Intravenous administration of antivenoms is associated with early adverse reactions in a number of cases, but the causes of this phenomenon are still unclear. The effect of preservatives (phenol and thimerosal) on IgG ...
Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP) for the treatment of viper envenoming in sub-Saharan Africa
(2010-02)
A preclinical assessment was performed on the neutralizing efficacy of a whole IgG polyspecific antivenom (EchiTAb-Plus-ICP®), designed for the treatment of snakebite envenomings in Nigeria. It was generated by immunizing ...
Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows
(2010-11)
Administration of antivenoms to treat snakebite envenomings has the potential risk of inducing early adverse reactions. The mechanisms involved in these reactions are unclear. In this study, polyspecific antivenom consisting ...
Modulation of the Susceptibility of Human Erythrocytes to Snake Venom Myotoxic Phospholipases A2: Role of Negatively Charged Phospholipids as Potential Membrane Binding Sites
(2001-07-01)
Cerrophidion (Bothrops) godmani myotoxins I (CGMT-I) and II (CGMT-II), Asp-49 and Lys-49 phospholipases A(2) (PLA2s), which drastically differ in enzymatic activity, were devoid of direct hemolytic effects on erythrocytes ...
Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without β-propiolactone, in the treatment of Bothrops asper bites in Colombia
(2006-12)
The efficacy and safety of two whole IgG polyvalent antivenoms (A and B) were compared in a randomised, blinded clinical trial in 67 patients systemically envenomed by Bothrops asper in Colombia. Both antivenoms were ...
Role of the animal model on the pharmacokinetics of equine-derived antivenoms
(2013-08)
Antivenom pharmacokinetics has been studied in heterologous models in which the animal species used as immunoglobulin source is different from that used as recipient. In these models, after intravenous administration of ...