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Mostrando ítems 731-740 de 913
Snake venomics, experimental toxic activities and clinical characteristics of human envenomation by Bothrocophias myersi (Serpentes: Viperidae) from Colombia
(2020)
Venoms of the viperid genus Bothrocophias, restricted to Colombia and Ecuador, are poorly known. Only a proteomic analysis of B. campbelli venom has been described. In this work we present a proteomic study of B. myersi ...
Cleavage of the NH2-Terminal Octapeptide of Bothrops asper Myotoxic Lysine-49 Phospholipase A2 Reduces Its Membrane-Destabilizing Effect
(1994-08)
Bothrops asper myotoxin II was cleaved with cyanogen bromide to determine the role of NH2-terminal amino acid residues in its ability to destabilize negatively charged liposomes and to induce myonecrosis. After treatment, ...
Physical characteristics of nano-Hydroxyapatite Pickering-emulsions and their adjuvant activity on the antibody response towards the Bothros asper snake venom
(2019)
Emulsions are crucial in the treatment of snake bites to bust the antibody response of the inmunogen. The widely used Freund's emulsion typically combines 50/50 water-oil (W/O) phase. However, its use is limited because ...
Inhibitory effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phospholipases A2 from Bothrops snake venoms: isolation of 4-nerolidylcatechol as active principle
(2005)
Phospholipases A2 (PLA2) are important constituents of snake venoms, being responsible for several of their toxic actions.
Extracts from plants used in folk medicine were screened for inhibition of the enzymatic activity ...
Combined venom gland cDNA sequencing and venomics of the New Guinea small-eyed snake, Micropechis ikaheka
(2014-10-14)
The venom arsenal of the New Guinea small-eyed snake, Micropechis ikaheka, was investigated by a joint cDNA sequencing and venomics approach. Twenty-seven full-length DNA sequences encoding novel venom proteins were recovered ...
Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A2 from the Central American coral snake, Micrurus nigrocinctus
(2017)
Snakebite envenomings represent a neglected public health issue in many parts of the
rural tropical world. Animal-derived antivenoms have existed for more than a hundred
years and are effective in neutralizing snake venom ...
Gene Expression Dynamics Induced by Ciprofloxacin and Loss of LexA Function in Pseudomonas aeruginosa PAO1 Using Data Mining and Network Analysis
(2018)
Pseudomonas aeruginosa is an opportunistic
pathogen that causes a variety of infections in humans and
frequently develops mechanisms of resistance to antibiotics, which
makes its treatment difficult. In this study we ...
Enterococci as a key parameter for water quality index: Purires River, Costa Rica
(2018)
This study used the Canadian Water Quality Index (CWI) to characterize water sampled at three points within the Purires River micro basin, Costa Rica. The first sampling point is located in a high zone with domestic ...
Development of nanobodies against hemorrhagic and myotoxic components of Bothrops atrox snake venom
(2020)
Snake envenoming is a globally neglected public health problem. Antivenoms produced using animal hyperimmune plasma remain the standard therapy for snakebites. Although effective against systemic effects, conventional ...