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Activation of the lytic program of the Epstein–Barr virus in Burkitt's lymphoma cells leads to a two steps downregulation of expression of the proapoptotic protein BimEL, one of which is EBV-late-gene expression dependent
(Virology 387 (2009) (1) p.41.49, 2009-02-28)
The Epstein–Barr virus (EBV) generally latently infects its target cells with expression of genes conferring resistance to apoptosis. However, the modulation of apoptotic signals during lytic cycle remains poorly understood. ...
Trends in Snakebite Envenomation Therapy: Scientific, Technological and Public Health Considerations
(2007)
The therapy of snakebite envenomation has been based on the parenteral administration of animal-derived antivenoms. Despite the success of this treatment at reducing the impact of snakebite mortality and morbidity, mostly ...
A geographical sampling strategy for field surveys in an urban area using high-resolution satellite imagery
(2006-11)
Field evaluations for studying the epidemiology of vector-borne diseases like dengue in urban areas are often restricted to selection of households and buildings for field surveys. Therefore, the resulting sampling frame ...
Consecuencias biológicas de las variaciones en los dominios de unión a receptor de toxina B de cepas clásicas e hipervirulentas de Clostridioides difficile
(2022)
Clostridioides difficile es un bacilo anaerobio estricto, Gram positivo y formador de
esporas. Es un patógeno oportunista que coloniza el colon del hospedero cuando se
altera la microbiota intestinal favoreciendo la ...
Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper
(1998-08)
Blister formation and skin damage can be induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper. Pathological changes in the skin were investigated after intramuscular injections of ...
The effect of myotoxins isolated from Bothrops snake venoms on multilamellar liposomes: relationship to phospholipase A2, anticoagulant and myotoxic activities
(1991-12)
The effect of four myotoxins isolated from Bothrops snake venoms on the release of peroxidase trapped in large multilamellar liposomes was studied and correlated to their phospholipase A2, myotoxic and anticoagulant ...
Strengthening antivenom production in Central and South American public laboratories: Report of a workshop
(2007-01)
A workshop on antivenom production in Central and South American public laboratories was performed at Instituto Butantan, Sao Paulo, Brazil, from June 12 to June 16, 2006, under the auspices of the program CYTED. The ...
SDS‑induced hexameric oligomerization of myotoxin‑II from Bothrops asper assessed by sedimentation velocity and nuclear magnetic resonance
(2023)
We report the solution behavior, oligomerization state, and structural details of myotoxin-II purified from the venom of
Bothrops asper in the presence and absence of sodium dodecyl sulfate (SDS) and multiple lipids, as ...
Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing
(BMC Genomics, 12:259, 2011, 2011)
Background: A long term research goal of venomics, of applied importance for improving current antivenom
therapy, but also for drug discovery, is to understand the pharmacological potential of venoms. Individually ...
CMV-encoded Fcγ receptors: modulators at the interface of innate and adaptive immunity
(2014-10-07)
The constant region of IgG antibodies mediates antiviral activities upon engaging host Fcγ receptors (FcγRs) expressed by a variety of immune cells, such as antibody-dependent cellullar cytotoxcity (ADCC) executed by natural ...