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Host response to Bothrops asper snake venom: analysis of edema formation, inflammatory cells, and cytokine release in a mouse model
(1993)
As part of tle characterization of the host reactivity to the venom of Bothrops
asper, we investigated the inflammatory responses in the mouse footpad model.
The subcutaneously iniected venom induced a rapid increase of ...
Insights into the mutation T1117I in the spike and the lineage B.1.1.389 of SARS-CoV-2 circulating in Costa Rica
(2022-06)
Emerging mutations and genotypes of the SARS-CoV-2 virus, responsible for the COVID-19 pandemic, have been reported globally. In Costa Rica during the year 2020, a predominant genotype carrying the mutation T1117I in the ...
Characterization of heterogeneous response to chemotherapy by perturbation-based modeling of fluorescent sphingolipid metabolism in cancer cell subpopulations
(2017)
Cancer treatments options are limited by the generation of therapy resistance, which is due by intratumoral heterogeneity in cell response. The study of resistance requires biosensors able to report the response at the ...
Terapias de modulación de la microbiota intestinal eficaces en la restauración inmunológica en conjunto con terapias anti-retrovirales en pacientes con VIH: Una revisión sistemática
(2023)
La inflamación crónica observada en los pacientes con virus de la inmunodeficiencia humana (VIH) es una problemática en el curso de la enfermedad y a pesar del tratamiento anti-retroviral (ART), la persistencia de la ...
Snake Venomics and Antivenomics of the Arboreal Neotropical Pitvipers Bothriechis lateralis and Bothriechis schlegelii
(2008-04-30)
We report the comparative proteomic characterization of the venoms of two related neotropical arboreal pitvipers from Costa Rica of the genus Bothriechis, B. lateralis (side-striped palm pit viper) and B. schlegelii (eyelash ...
Phenotypic and Genotypic Characterization of Multidrug-Resistant Bacteroides, Parabacteroides spp., and Pseudoflavonifractor from a Costa Rican Hospital
(2014-09)
Multidrug resistance in Bacteroides spp. and related genera is uncommon and has not been described in Latin America until now. We studied phenotypically and genotypically the multidrug resistance of 10 clinical strains of ...
Desarrollo de la respuesta de anticuerpos anti-fosfolipasa A, en caballos inoculados con veneno para la producción de suero antiofídico polivalente en Costa Rica
(1989)
The development of antibody response against phospholipase A activity of Bothrops asper venom was studied in a group of adult and healthy horses used in the production ofthe polyvalent antivenom at the Instituto Clodomiro ...
Snake venom Lys49 myotoxins: from phospholipases A2 to non-enzymatic membrane disruptors
(2012-09)
Snake venoms often contain toxins that cause a rapid necrosis of skeletal muscle fibers,
referred to as myotoxins. The most common among them are phospholipases A2 (PLA2s),
enzymes that have two independent evolutionary ...
Stability, distribution and use of antivenoms for snakebite envenomation in Latin America: Report of a workshop
(2009-05)
The issues of antivenom stability and distribution, and the training of health staff in the correct use of antivenoms in Latin America were discussed in a workshop held at Instituto Clodomiro Picado, Costa Rica, in September ...