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Cyclin-dependent kinase 4/6 inhibitors as first-line treatment for post-menopausal metastatic hormone receptor-positive breast cancer patients: a systematic review and meta-analysis of phase III randomized clinical trials.
(2018)
Background
To compare the efficacy and toxicity of the combination of cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors and nonsteroidal aromatase inhibitors (AI) versus AI alone as first-line therapy for patients with ...
Análisis de la situación epidemiológica y manejo actual de los sarcomas de tejido blando y hueso en el Hospital México, San José Costa Rica
(2018-08)
Antecedente: Los sarcomas de tejido blando y de hueso, son
tumores raros, que son más frecuentes en la población joven.
Existen varios subtipos y cada uno de ellos debe ser tratados
en forma individual. Este es un ...
Continuing education for forensic medical analysis of the constitutional appeals in Costa Rica
Formación académica continua para el análisis médico forense de recursos de amparo en Costa Rica
Formação acadêmica contínua para análise médico forense de recursos de amparo na Costa Rica
(2023-11-10)
Introduction: Judicially demanding the right to health involves different elements and can lead to changes in continuing education programs. The current trend is to follow this pathway to access low-frequency and high-cost ...
Differential effect of environment enrichment and social isolation on depressive-like behavior, spontaneous activity and serotonin and norepinephrine concentration in prefrontal cortex and ventral striatum
(2008)
Dawley rats were reared from weaning in either social isolation, standard laboratory conditions, or environmental enrichment. Open-field activity
was assessed at postnatal days 37, 65, 93 and 107 and 1 h before the last ...
Physiological wear-and-tear and later subjective health in mid-life: Findings from the 1958 British birth cohort
(2016)
Our body adapts continuously to environmental challenges and stressful conditions. Allostatic load (AL) is a concept that aims to capture the overall physiological wear-and-tear of the body triggered by the repeated ...
La formación de estudiantes de Odontología en Bioquímica: Un desafío para la docencia universitaria en la producción de un libro de texto
(2017-05-01)
La formación en bioquímica de los estudiantes de odontología es un desafío para la docencia en la Universidad de Costa Rica. Para tratar de abordar este problema se propuso realizar un libro de texto de bioquímica ...
Maternal behavior as an early modulator of neurobehavioral offspring responses by Sprague-Dawley rats
(2013)
Maternal care plays an important role as an early modeler of neurodevelopment and brain function,
and its effects remain until adulthood. Such modeling or programming has shown to influence the
stress response and ...
Paracoccidiodomicosis (Reporte de siete casos)
Paracoccidiodomycosis (Report of seven cases)
(Revista Médica de Costa Rica y Centroamérica, tomo 65, número 582, p.41-47, 2008)
Paracoccidiomycosis is an illness produced by dimorphic fungi (Paracoccidiodes Brasiliensis) that can affect various organs, among them skin and mucous membranes, lymph nodes, lungs, bones, adrenal glands, the vascular and ...
Verteporfin targeting YAP1/TAZ-TEAD transcriptional activity inhibits the tumorigenic properties of gastric cancer stem cells
(2019)
Gastric carcinomas (GC) are heterogeneous tumors, composed of a subpopulation of cluster of differentiation-44 (CD44)+ tumorigenic and chemoresistant cancer stem cells (CSC). YAP1 and TAZ oncoproteins (Y/T) interact with ...