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dc.creatorMinero, Miguel Angel
dc.creatorChinchilla Carmona, Misael
dc.creatorGuerrero Bermúdez, Olga Marta
dc.creatorCastro Castillo, Alfredo
dc.date2014-06-19
dc.date.accessioned2016-05-03T15:29:25Z
dc.date.available2016-05-03T15:29:25Z
dc.identifierhttp://revistas.ucr.ac.cr/index.php/rbt/article/view/14942
dc.identifier.urihttp://hdl.handle.net/10669/26628
dc.descriptionInfection and multiplication of Leishmania infantum and L. mexicana inside of skin fibroblasts from hamsters, mice and rats was achieved. This process was demonstrated either by counting parasites inside the stained cells or by electronic microscopy studies. In addition multiplication rate differences in the cells from these rodent species were determined, for L. infantum as well as for L. mexicana. Parasite development in hamsters and mice fibroblasts was evident but there was not multiplication in rat cells showing that apparently they are refractory to Leishmania infection. These results suggest that the parasite affinity for each animal, as well as any intracellular environment resistance, could involve genetic factors in the parasite multiplication. On the other hand, presence of amastigote multiplication inside of parasitophorus vacuole, showed by electronic microscopy images, probes a true parasite transformation. Therefore it is suggested that fibroblasts could work as host cells for parasite survival and permanency in the infected animals.es-ES
dc.descriptionInfection and multiplication of Leishmania infantum and L. mexicana inside of skin fibroblasts from hamsters, mice and rats was achieved. This process was demonstrated either by counting parasites inside the stained cells or by electronic microscopy studies. In addition multiplication rate differences in the cells from these rodent species were determined, for L. infantum as well as for L. mexicana. Parasite development in hamsters and mice fibroblasts was evident but there was not multiplication in rat cells showing that apparently they are refractory to Leishmania infection. These results suggest that the parasite affinity for each animal, as well as any intracellular environment resistance, could involve genetic factors in the parasite multiplication. On the other hand, presence of amastigote multiplication inside of parasitophorus vacuole, showed by electronic microscopy images, probes a true parasite transformation. Therefore it is suggested that fibroblasts could work as host cells for parasite survival and permanency in the infected animals.en-US
dc.formatapplication/pdf
dc.languagespa
dc.publisherUniversidad de Costa Ricaen-US
dc.rightsCopyright (c) 2014 International Journal of Tropical Biology and Conservationen-US
dc.sourceRevista de Biología Tropical/International Journal of Tropical Biology and Conservation; Vol.52 (1) March 2004; 261-267en-US
dc.sourceRevista de Biología Tropical/International Journal of Tropical Biology and Conservation; Vol.52 (1) March 2004; 261-267es-ES
dc.sourceRevista Biología Tropical; Vol.52 (1) March 2004; 261-267pt-PT
dc.source2215-2075
dc.source0034-7744
dc.subjecttrypanosomatidae; leishmania; cell culture; fibroblasts
dc.titleInfección de fibroblastos de piel de animales con distinto grado de susceptibilidad a Leishmania infantum y Leishmania mexicana (Kinetoplastida: Trypanosomatidae)es-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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