Listar Biología por autor "Cao, Shugeng"

Mostrando ítems 1-4 de 4

    • A High-Throughput Screen Identifies a New Natural Product with Broad-Spectrum Antibacterial Activity 

      Ymele Leki, Patrick; Cao, Shugeng; Sharp, Jared ; Lambert, Kathleen G.; McAdam, Alexander J.; Husson, Robert N.; Tamayo Castillo, Giselle ; Clardy, Jon; Watnick, Paula I. (2012)
      Due to the inexorable invasion of our hospitals and communities by drug-resistant bacteria, there is a pressing need for novel antibacterial agents. Here we report the development of a sensitive and robust but low-tech and ...

    • Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts 

      Cheng, Ken Chih-Chien; Cao, Shugeng; Raveh, Avi; MacArthur, Ryan; Dranchak, Patricia; Chlipala, George E.; Okoneski, Matthew T.; Guha, Rajarshi; Eastman, Richard T.; Yuan, Jing; Schultz, Pamela J.; Su, Xin-zhuan; Tamayo Castillo, Giselle; Matainaho, Teatulohi; Clardy, Jon; Sherman, David H.; Inglese, James (2015)
      Methods to identify the bioactive diversity within natural product extracts (NPEs) continue to evolve. NPEs constitute complex mixtures of chemical substances varying in structure, composition, and abundance. NPEs can ...

    • Diketopiperazines from Costa Rican endolichenic fungus Colpoma sp. CR1465A 

      Lee, Seulah; Tamayo Castillo, Giselle; Pang, Changhyun; Clardy, Jon; Cao, Shugeng; Kim, Ki Hyun (2016-05-15)
      Three new diketopiperazines (1–3), cyclo(l-Pro-d-trans-Hyp) (1), cyclo(l-Pro-d-Glu) (2), and cyclo(d-Pro-d-Glu) (3) and five known diketopiperazines (4–8) were isolated from the endolichenic fungus Colpoma sp. CR1465A ...

    • Inhibition of Tumor Cells Interacting with Stromal Cells by Xanthones Isolated from a Costa Rican Penicillium sp. 

      Cao, Shugeng; McMillin, Douglas W.; Tamayo Castillo, Giselle; Delmore, Jake; Mitsiades, Constantine S.; Clardy, Jon (2012)
      CR1642D, an endophytic isolate of Penicillium sp. collected from a Costa Rican rainforest, was identified through a high-throughput approach to identify natural products with enhanced antitumor activity in the context of ...