Listar Biología por autor "De Ford, Christian"
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Discovery of Tricyclic Clerodane Diterpenes as Sarco/Endoplasmic Reticulum Ca2+-ATPase Inhibitors and Structure−Activity Relationships
De Ford, Christian; Calderón Castro, Carlos; Sehgal, Pankaj; Fedosova, Natalya U.; Murillo Masís, Renato; Olesen, Claus; Nissen, Poul; Møller, Jesper V.; Merfort, Irmgard (2015-05-20)Tricyclic clerodane diterpenes (TCDs) are natural compounds that often show potent cytotoxicity for cancer cells, but their mode of action remains elusive. A computationally based similarity search (CDRUG), combined with ... -
The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling
De Ford, Christian; Heidersdorf, B.; Haun, F.; Merfort, Irmgard; Murillo Masís, Renato; Friedrich, T.; Borner, C. (2016-01-28)T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy that preferentially affects children and adolescents. Over 50% of human T-ALLs possess activating mutations of Notch1. The clerodane ...