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Now showing items 1-17 of 17
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Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis
(2015)Oral squamous cell carcinoma (OSCC) is the most common cancer affecting the oral cavity, and US clinics will register about 30,000 new patients in 2015. Current treatment modalities include chemotherapy, surgery, and ... -
Brachiopods, sipunculans, enteropneusts and metals from two estuarine tidal flats, Pacific, Costa Rica
(2016-09)Reports on the abundances and on metal concentrations in intertidal estuarine invertebrates from the Eastern Tropical Pacific are rare. Thus, the objectives of this report are to make accessible data on the abundances ... -
Composition of the essential oil from leaves of Smallanthus quichensis (Asteraceae) from Costa Rica
(2015-09-30)Smallanthus is a genus of flowering plants in the Asteraceae family, which has about 24 species, ranging mostly from southern Mexico and Central America to the Andes in South America. The aim of the present study was to ... -
Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments
(2017)High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal ... -
Discovery of Tricyclic Clerodane Diterpenes as Sarco/Endoplasmic Reticulum Ca2+-ATPase Inhibitors and Structure−Activity Relationships
(2015-05-20)Tricyclic clerodane diterpenes (TCDs) are natural compounds that often show potent cytotoxicity for cancer cells, but their mode of action remains elusive. A computationally based similarity search (CDRUG), combined with ... -
Essential oil composition of Ambrosia cumanensis (Asteraceae) from Costa Rica
(2015-08)Ambrosia is an Asteraceous genus of flowering plants, which has about 40-45 species, and their geographical distribution ranges from the USA, Mexico, and Central America to South America. The aim of this work was to study ... -
Genetic analysis of the dry forest timber tree Sideroxylon capiri in Costa Rica using AFLP
(2015-01)Sideroxylon capiri (“Tempisque”) is a threatened and economically important timber species in the dry forest of Costa Rica. To assess the extent of the genetic diversity between and within populations of this species, 86 ... -
Interplay of the PtsN (EIIANtr) protein of Pseudomonas putida with its target sensor kinase KdpD
(2015-08-27)The nitrogen phosphotransferase system (PTSNtr) of Pseudomonas putida is a multi-component regulatory device that participates in controlling a variety of physiological processes in a post-translational fashion. A general ... -
Leaf and flower essential oil compositions of Gliricidia sepium (Fabaceae) from Costa Rica
(2015-04)Gliricidia is a small genus of flowering plants in the Fabaceae family. Gliricidia sepium is a multipurpose tree native to Mesoamerica and possibly northern South America. The chemical composition of the hydrodistilled ... -
Mastering analytical challenges for the characterization of pentacyclic triterpene mono- and diesters of Calendula officinalis flowers by non-aqueous C30 HPLC and hyphenation with APCI-QTOF-MS
(2016-01-25)Pentacyclic triterpene mono- and diesters have been isolated from Calendula officinalis flowers. GC–MS, APCI-Exactive Orbitrap HR-MS and NMR allowed to identify the triterpene skeleton in various samples (different triterpene ... -
Novel Lobophorins Inhibit Oral Cancer Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts
(2015-07-06)As part of the International Cooperative Biodiversity Groups (ICBG) Program, we were interested in identifying biologically active unfolded protein response (UPR) inducing compounds from marine microorganisms isolated from ... -
Production of selenium nanoparticles in Pseudomonas putida KT2440
(2016)Selenium (Se) is an essential element for the cell that has multiple applications in medicine and technology; microorganisms play an important role in Se transformations in the environment. Here we report the previously ... -
Quantitative Physiology Approaches to Understand and Optimize Reducing Power Availability in Environmental Bacteria
(2015-06-04)The understanding of how carbon fluxes are distributed through a metabolic network offers an overview of the pathways that a given microorganism uses to produce energy, reducing power, and biomass. These invaluable data ... -
Richness of cultivable endophytic fungi along an altitudinal gradient in wet forests of Costa Rica
(2016-04)We collected various plant species along an altitudinal gradient ranging from 400 to 2900 m in tropical wet forests of Costa Rica, isolated the associated endophytic fungi, and performed bioinformatic analyses to determine ... -
Simple route for nano-hydroxyapatite properties expansion
(2015-10-20)Simple surface modification of nano-hydroxyapatite, through acid-basic reactions, allows expanding the properties of this material. Introduction of organic groups such as hydrophobic alkyl chains, carboxylic acid, and amide ... -
Study of the diversity of culturable actinomycetes in the North Pacific and Caribbean coasts of Costa Rica
(2009)In this study, 137 actinomycetes were isolated from subtidal marine sediments in the North Pacific and Caribbean coasts of Costa Rica. Bioinformatics analysis of the 16S rRNA gene sequences assigned the isolates to 15 ... -
The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling
(2016-01-28)T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy that preferentially affects children and adolescents. Over 50% of human T-ALLs possess activating mutations of Notch1. The clerodane ...