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Concomitant prediction of environmental fate and toxicity of chemical compounds
(2020)
The environmental fate of many functional molecules that are produced on a large scale as precursors or as additives to specialty goods (plastics, fibers, construction materials, etc.), let alone those synthesized by the ...
ArsH protects Pseudomonas putida from oxidative damage caused by exposure to arsenic
(2020-03-23)
The two As resistance arsRBC operons of Pseudomonas putida KT2440 are followed by a downstream gene called arsH that encodes an NADPH‐dependent flavin mononucleotide reductase. In this work, we show that the arsH1 and (to ...
A Metabolic Widget Adjusts the Phosphoenolpyruvate-Dependent Fructose Influx in Pseudomonas putida
(2016)
Fructose uptake in the soil bacterium Pseudomonas putida occurs through a canonical phosphoenolpyruvate (PEP)-dependent sugar transport system (PTSFru). The logic of the genetic circuit that rules its functioning is puzzling: ...
Transcriptional control of 2,4-dinitrotoluene degradation in Burkholderia sp. R34 bears a regulatory patch that eases pathway evolution
(2021-05)
The dnt pathway of Burkholderia sp. R34 is in the
midst of an evolutionary journey from its ancestral,
natural substrate (naphthalene) towards a new xenobiotic
one [2,4-dinitrotoluene (DNT)]. The gene cluster
encoding ...
Low CyaA expression and anti‐cooperative binding of cAMP to CRP frames the scope of the cognate regulon of Pseudomonas putida
(2021-03)
Although the soil bacterium Pseudomonas putida
KT2440 bears a bona fide adenylate cyclase gene
(cyaA), intracellular concentrations of 30,50-cyclic
adenosine monophosphate (cAMP) are barely detectable.
By using reporter ...
Reconfiguration of metabolic fluxes in Pseudomonas putida as a response to sub-lethal oxidative stress
(2021-01-11)
As a frequent inhabitant of sites polluted with toxic chemicals, the soil bacterium and plant-root colonizer Pseudomonas
putida can tolerate high levels of endogenous and exogenous oxidative stress. Yet, the ultimate ...