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Bioassay-guided isolation of anti-inflammatory O-sulfated withanolides from Acnistus arborescens (Solanaceae)
(2019)
Bioassay-guided fractionation of Acnistus arborescens (Solanaceae) organic extract afforded two anti-inflammatory withanolides: 2,3-Dihydro-3β-O-sulfate withacnistin (1) and 2,3-Dihydro-3β-O-sulfate withaferin A (2) showing ...
Crystal structure of (E)-2-(tert-butylamino)-4-(tertbutylimino)naphthalen-1(4H)-one
(2018)
The title compound, C18H24N2O, is the first example of a naphthoquinone imine derivative isolated in the 4-imine/2-amine tautomeric form having bulky alkyl substituents at the N atoms. The molecular conformation is stabilized ...
Critical Assessment of pH-Dependent Lipophilicity Profiles of Small Molecules: Which One Should We Use and In Which Cases?
(2023-10-03)
Lipophilicity is a physicochemical property with wide relevance in drug design, computational biology, food, environmental and medicinal chemistry. Lipophilicity is commonly expressed as the partition coefficient for neutral ...
Efficient syntheses of streptocarpone and (±)-a-dunnione
(2007)
An efficient divergent synthesis of both streptocarpone and racemic α-dunnione from lawsone are described. A one-pot, formal [3+2] cyclization to form a furanonaphthoquinone directly provided a common intermediate.
Synthesis of N-[3-(prop-1-yn-1-yl)phenyl] benzene sulfonamide and Determination of its Antibacterial Activity
(2019-07-25)
The synthesis of N-[3-(prop-1-yn-1-yl)phenyl] benzenesulfonamide was performed and its antibacterial activity against Staphylococcus aureus and Escherichia coli was determined. Minimalinhibitory concentrations (MIC) of ...
Una nueva ruta para la sintesis de la feromona sexual de la polilla de la papa, Scrobipalpopsis solanivora
(1996)
Acetato de (E)-3-dodecenilo, principal componente de feromona de Scrobipal-popsis solanivora, se preparó con un rendimiento total del 61 %. El precursor, 3-dodecin-1-ol, se preparó en el paso de un recipiente mediante la ...
Análisis de residuos de plomo en repollo de Costa Rica
(1984)
Lead residues analysis in cabbage. Cabbage and soil samples from the main cabbage growing areas of Costa Rica were analyzed for lead residues. Lead residues result from the use of lead arseniate as an insecticide and ...
Identification of Protein Kinase C Activation as a Novel Mechanism for RGS2 Protein Upregulation through Phenotypic Screening of Natural Product Extracts
(2014)
Biochemical high-throughput screening is widely used in drug discovery, using a variety of small molecule libraries. However, broader screening strategies may be more beneficial to identify novel biologic mechanisms. In ...
Bis(μ2-benzoato-κ2O,O′)bis(benzoato-κO)bis(ethanol-κO)bis(μ3-hydroxido)hexakis(μ-pyrazolato-κ2N,N′)hexacopper(II) ethanol disolvate
(2019)
Trinuclear copper–pyrazolate entities are present in various Cu-based enzymes and nanojar supramolecular arrangements. The reaction of copper(II) chloride with pyrazole (pzH) and sodium benzoate (benzNa) assisted by ...
Essential oil from leaves of Myrcianthes fragrans (Myrtaceae) from Costa Rica. A new chemotype?
Aceite esencial de las hojas de Myrcianthes fragrans (Myrtaceae) de Costa Rica. ¿Un nuevo quimiotipo?
(2017)
Myrcianthes is a Myrtaceous genus of flowering plants of about 30 to 40 species, distributed in the American continent. The aim of this work was to study the chemical composition of the foliar essential oil from M. fragrans ...