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dc.creatorGené, José Antonio
dc.creatorRoy Sund, Astrid
dc.creatorRojas Céspedes, Gustavo
dc.creatorGutiérrez, José María
dc.creatorCerdas Fallas, Luis
dc.date.accessioned2016-11-07T17:28:31Z
dc.date.available2016-11-07T17:28:31Z
dc.date.issued1989
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/0041010189900962es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/29156
dc.description.abstractThe coagulant, defibrinating, fibrino lytic and fibrinogenolytic activities of venoms from ten species of Costa Rican crotaline snakes were studied, together with the neutralization of these effects by a polyvalent antivenom. The venoms of Bothrops asper, B. schlegelii, B. nummifer, B. godmani, Lachesis muta and Crotalus durissus induced a coagulant effect in vitro, and all of them, with the exception of B. nummifer, also induced defibrination in vivo. The four non-coagulant venoms (B. lateralis, B. ophryomegas, B. nasuta and B. picadoi) induced a degradation of the alpha (A) chain of fibrinogen, thereby inhibiting coagulation. However, they did not induce defibrination upon i.v. injection. All of the venoms showed fibrinolytic activity in vitro. Polyvalent antivenom was effective in the neutralization of coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of these venoms, with the exception of coagulant effect induced by C. durissus venom. Since only three venoms are used in the immunization of horses, these results demonstrate the high degree of immunological cross reactivity between components affecting coagulation in Costa Rican crotaline snake venoms.es_ES
dc.language.isoen_USes_ES
dc.sourceToxicon Volumen 27, Número 8, 1989es_ES
dc.subjectAnimalses_ES
dc.subjectAntiveninses_ES
dc.subjectCoagulantses_ES
dc.subjectCosta Ricaes_ES
dc.subjectCrotalid Venomses_ES
dc.subjectFibrinogenes_ES
dc.subjectFibrinolytic Agentses_ES
dc.subjectHumanses_ES
dc.subjectIn Vitro Techniqueses_ES
dc.subjectMicees_ES
dc.subjectSheepes_ES
dc.subjectSnake venomes_ES
dc.titleComparative study on coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenomes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/0041-0101(89)90096-2
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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