Show simple item record

dc.creatorDíaz Oreiro, Cecilia
dc.creatorGutiérrez, José María
dc.creatorLomonte, Bruno
dc.creatorNúñez, Javier
dc.date.accessioned2016-11-11T14:34:54Z
dc.date.available2016-11-11T14:34:54Z
dc.date.issued1993-09
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/29228
dc.description.abstractModification of Bothrops asper myotoxin II, a lysine-49 phospholipase A2 variant, was carried out with p-bromophenacyl bromide. Modified toxin did not show changes in its charge and immunological properties but two of its pharmacological activities were modified. Myotoxic activity, measured by histology and by increment of creatine kinase levels in plasma of mice, was significantly reduced after toxin modification. In addition, liposome disruption activity was also significantly lower with the modified toxin both at 3 and 24 hr of incubation with the alkylating reagent. Some of the implications of these results on the structure-function relationship of myotoxins are discussed.es_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 31, Número 9, 1993es_ES
dc.subjectAcetophenoneses_ES
dc.subjectAnimalses_ES
dc.subjectCreatine Kinasees_ES
dc.subjectCrotalid Venomses_ES
dc.subjectElectrophoresis, Polyacrylamide Geles_ES
dc.subjectEnzyme-Linked Immunosorbent Assayes_ES
dc.subjectGroup II Phospholipases A2es_ES
dc.subjectLiposomeses_ES
dc.subjectLysinees_ES
dc.subjectMicees_ES
dc.subjectNeurotoxinses_ES
dc.subjectPeroxidaseses_ES
dc.subjectPhospholipases Aes_ES
dc.subjectPhospholipases A2es_ES
dc.subjectReptilian Proteinses_ES
dc.titlep-Bromophenacyl bromide modification of Bothrops asper myotoxin II, a lysine-49 phospholipase A2, affects its pharmacological activitieses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/0041-0101(93)90136-7
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record