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dc.creatorMoreira, Vanessa
dc.creatorGutiérrez, José María
dc.creatorAmaral, Rafaela Bacci
dc.creatorZamunér, Stella Regina
dc.creatorTeixeira, Catarina de Fátima
dc.creatorAmaral, Rafaela Bacci
dc.date.accessioned2016-11-16T20:11:39Z
dc.date.available2016-11-16T20:11:39Z
dc.date.issued2009-03
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0952327808001841es_ES
dc.identifier.issn0952-3278
dc.identifier.urihttp://hdl.handle.net/10669/29258
dc.description.abstractIn this study, the ability of Bothrops asper snake venom (BaV) to increase the production of prostaglandins PGE2 and PGD2 was assessed in a mouse model in vivo and in inflammatory cells in vitro. In addition, the expressions of COX-1 and COX-2 were assessed. BaV induced an increment in the in vivo synthesis of PGE2 and PGD2, together with an enhanced expression of COX-2, but not of COX-1. However, enzymatic activities of COX-1 and COX-2 were increased. Incubation of isolated macrophages and neutrophils with a sub-cytotoxic concentration of BaV in vitro resulted in increased release of PGE2 and PGD2 by macrophages and PGE2 by neutrophils, concomitantly with an increment in the expression of COX-2, but not of COX-1 by both cell types. Our results demonstrate the ability of BaV to promote the expression of COX-2 and to induce the synthesis of proinflammatory prostaglandins. Macrophages and neutrophils may be important targets for this venom under in vivo situation.es_ES
dc.language.isoen_USes_ES
dc.sourceProstaglandins, Leukotrienes and Essential Fatty Acids; Volumen 80, Número 2-3. 2009es_ES
dc.subjectCyclooxygenaseses_ES
dc.subjectNeutrophiles_ES
dc.subjectMacrophagees_ES
dc.subjectSnake venomes_ES
dc.titleEffects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitroes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.plefa.2008.11.009
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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