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dc.creatorGutiérrez, José María
dc.creatorLomonte, Bruno
dc.creatorLeón Montero, Guillermo
dc.creatorAlape Girón, Alberto
dc.creatorFlores Díaz, Marietta
dc.creatorSanz, Libia
dc.creatorAngulo Ugalde, Yamileth
dc.creatorCalvete Chornet, Juan José
dc.date.accessioned2016-11-16T20:37:01Z
dc.date.available2016-11-16T20:37:01Z
dc.date.issued2009-03-06
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S1874391909000128es_ES
dc.identifier.issn1874-3919
dc.identifier.urihttp://hdl.handle.net/10669/29259
dc.description.abstractSnakebite envenoming represents a neglected tropical disease that has a heavy public health impact, particularly in Asia, Africa and Latin America. A global initiative, aimed at increasing antivenom production and accessibility, is being promoted by the World Health Organization and others. This work discusses several aspects of antivenom manufacture and control in which the proteomic analysis of snake venoms, for which the term ‘snake venomics’ has been coined, might play a relevant supporting role. Snake venomics has already shown its usefulness for generating knowledge at different levels (ontogenetic, individual, and geographic) on inter- and intraspecies venom variability. This information has applications for the quality control of venom preparations used in antivenom manufacture. Moreover, the design of the best venom mixtures for immunization, aimed at increasing the effectiveness of antivenoms, may also be guided by venom proteome analysis, including molecular studies of the cross-reactivity of antivenoms and heterologous venoms through a recently developed methodological approach termed ‘antivenomics’. Results generated by proteomic protocols should be complemented by preclinical testing of antivenom efficacy using functional neutralization assays. Snake venomics might be also helpful in designing alternative in vitro tests for the assessment of antivenom efficacy that would eventually substitute current in vivo tests.es_ES
dc.description.sponsorshipConsejo Superior de Investigaciones Científicas (CSIC), project 2007CR0004es_ES
dc.description.sponsorshipCYTED, project 206AC0281es_ES
dc.description.sponsorshipUniversidad de Costa Rica, project 741-A8-521es_ES
dc.description.sponsorshipConsejo Nacional de Rectores (CONARE), Costa Ricaes_ES
dc.description.sponsorshipMinisterios de Educación y Ciencia and Ciencia e Innovación, Madrid, grants BFU2004-01432 and BFU2007-61563es_ES
dc.description.sponsorshipAcciones Integradas 2006CR0010es_ES
dc.language.isoen_USes_ES
dc.sourceJournal of Proteomics; Volumen 72, Número 2. 2009es_ES
dc.subjectProteomics of snake venomses_ES
dc.subjectVenomicses_ES
dc.subjectAntivenomses_ES
dc.subjectAntivenomicses_ES
dc.subjectPreclinical testinges_ES
dc.subjectSnake venomes_ES
dc.titleSnake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenominges_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.jprot.2009.01.008
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicinaes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Estructuras Microscópicas (CIEMIC)es_ES


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