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Desarrollo de la respuesta de anticuerpos anti-fosfolipasa A, en caballos inoculados con veneno para la producción de suero antiofídico polivalente en Costa Rica
dc.creator | Estrada Umaña, Ricardo | |
dc.creator | Gutiérrez, José María | |
dc.creator | Alvarado, Jorge | |
dc.creator | Robles, Abel | |
dc.creator | Ávila Agüero, Claudio | |
dc.creator | González, Nuria | |
dc.date.accessioned | 2016-11-21T01:54:06Z | |
dc.date.available | 2016-11-21T01:54:06Z | |
dc.date.issued | 1989 | |
dc.identifier.issn | 2215-2075 | |
dc.identifier.uri | https://hdl.handle.net/10669/29272 | |
dc.description.abstract | The development of antibody response against phospholipase A activity of Bothrops asper venom was studied in a group of adult and healthy horses used in the production ofthe polyvalent antivenom at the Instituto Clodomiro Picado. Simultaneously, the general condition of the animals during the immunization schedule was also studied. There was a great individual variability in me ¡mmune response, although most of the horses studied reached the highest neutralizing titer aftrr injection of doses of venom of 30 mg and 50 mg. On the other hand, in horses that had been previously imnmunized and were injected for a second immunization, the highest antibody titer was observed 16-22 days after inoculation. There were only mild alterations in the general condtion of the horses as a consequence of venom inoculation. However, local abscesses, fistules and fibrosis were observed at the site of venom injection. On the basis of the conspicuous individual variability observed, it is proposed that the immune response in horses used in the production of antivenom must be evaluated on individual basis, instead of working with pools of serum samples. | es_ES |
dc.language.iso | es | es_ES |
dc.source | Revista de Biología Tropical; Volumen 37, Número 2, 1989 | es_ES |
dc.subject | Bothrops | es_ES |
dc.subject | Crotalus | es_ES |
dc.subject | Lachesis | es_ES |
dc.subject | Antibodies | es_ES |
dc.subject | Antivenom | es_ES |
dc.subject | Anti-phospholipase antiofídico | es_ES |
dc.subject | Anti-fosfolipasa | es_ES |
dc.title | Desarrollo de la respuesta de anticuerpos anti-fosfolipasa A, en caballos inoculados con veneno para la producción de suero antiofídico polivalente en Costa Rica | es_ES |
dc.type | artículo original | |
dc.identifier.doi | 10.15517/rbt.v37i2.23584 | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP) | es_ES |