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Snake venomics of Bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: different evolutionary solutions for the same trophic purpose

Artículo científico
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296_2010_J.Prot.Research_Fernandez_B.nigroviridis_proteome.pdf (1.027Mb)
Date
2010
Author
Fernández Ulate, Julián
Lomonte, Bruno
Sanz, Libia
Angulo Ugalde, Yamileth
Gutiérrez, José María
Calvete Chornet, Juan José
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Abstract
We report the proteomic characterization and biological activities of the venom of the black-speckled palm pitviper, Bothriechis nigroviridis, a neotropical arboreal pitviper from Costa Rica. In marked contrast to other Bothriechis species investigated, the venom of B. nigroviridis does not possess detectable Zn2+-dependent metalloproteinases, and is uniquely characterized by a high content of crotoxin-like PLA2 and vasoactive peptides. These data suggest that different evolutionary solutions have evolved within the arboreal genus Bothriechis for the same trophic purpose. The venom from B. nigroviridis is devoid of hemorrhagic activity, has low edematogenic and coagulant effects, presents modest myotoxic and phospholipase A2 activities, but has higher lethality than the venoms of other Bothriechis species. Neutralization of its lethal activity by an anti-Crotalus durissus terrificus antivenom confirmed the major role of crotoxin-like PLA2 in B. nigroviridis venom-induced lethality.
URI
http://hdl.handle.net/10669/29314
External link to the item
10.1021/pr100545d
http://pubs.acs.org/doi/abs/10.1021/pr100545d
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  • Microbiología [829]


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  • Repositorios universitarios

  • Repositorio del SIBDI-UCR
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  • Biblioteca Digital Carlos Melendez (CIHAC)
  • Repositorio de Fotografías
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  • Buscador regional de LA Referencia
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  • Scientific Electronic Library Online (SciELO)
  • Directory of Open Access Journals (DOAJ)
  • Redalyc
  • Redes sociales

  • facebook.com/repositoriokerwa
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Contact Us | Send Feedback
Repositorio Institucional de la Universidad de Costa Rica. Algunos derechos reservados. Este repositorio funciona con DSpace.
Universidad de Costa Rica